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Small cell lung cancer, endocrine cells of the fetal bronchus, and other
neuroendocrine cells express the Leu-7 antigenic determinant present on
natural killer cells
PA Bunn , I Linnoila, JD Minna, D Carney and AF Gazdar
Small cell lung cancer is distinguished from other lung cancer histologic
types by possessing a variety of neuroendocrine properties. Anti-Leu-7 is a
monoclonal antibody that recognizes a 110,000-dalton molecular weight
glycoprotein initially described on natural killer cells and subsequently
reported on a variety of normal and malignant neural and neuroendocrine
cell types. We have found intense anti-Leu-7 binding to a large number of
small cell lung cancers, while other lung cancer types were negative or
showed only weak and focal binding. Other antigens expressed by natural
killer cells, lymphocytes, and monocytes were never or less often expressed
on small cell lung cancer cells. In addition, we report for the first time
anti-Leu-7 binding by carcinoids, carotid body tumors, pheochromocytomas,
endocrine cells of the fetal bronchus and the adult intestine, and select
pancreatic islet cells. Anti-Leu-7 binding by small cell lung cancer is
consistent with a derivation from pulmonary precursor cells, and anti-Leu-7
staining is clinically useful for the identification of human
neuroendocrine tumors of the amine precursor uptake and decarboxylation
("APUD") type.
Volume 65,
Issue 3,
pp. 764-768,
03/01/1985
Copyright © 1985 by The American Society of Hematology
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