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A monoclonal antibody-defined membrane antigen complex is required for neutrophil-neutrophil aggregation

BR Schwartz, HD Ochs, PG Beatty and JM Harlan

We examined the aggregation responses of normal neutrophils treated with the murine monoclonal antibody (MoAb) 60.3. Addition of MoAb 60.3 to normal neutrophils produced dose-dependent inhibition of neutrophil aggregation in response to phorbol myristate acetate, zymosan-activated plasma, and N-formyl-methionylleucylphenylalanine. We conclude that the membrane glycoprotein complex recognized by MoAb 60.3--designated CDw18- -is required for neutrophil-neutrophil aggregation in vitro.

Volume 65, Issue 6, pp. 1553-1556, 06/01/1985
Copyright © 1985 by The American Society of Hematology


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  Copyright © 1985 by American Society of Hematology         Online ISSN: 1528-0020