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Impaired factor X and prothrombin activation associated with decreased
phospholipid exposure in platelets from a patient with a bleeding disorder
J Rosing, EM Bevers, P Comfurius, HC Hemker, G van Dieijen, HJ Weiss and RF Zwaal
Platelets from a platelet factor 3-deficient patient, which was first
described by Weiss et al (Am J Med 67:206, 1979), were found to be equally
impaired in their ability to promote factor X and prothrombin activation.
Compared to normal platelets, the patient's platelets showed upon
stimulation with thrombin plus collagen a much slower generation and a
considerably lower level of platelet prothrombin- and factor X-converting
activities. Treatment of stimulated platelets with phospholipases revealed
a decreased exposure of negatively charged phospholipid at the outer
surface of the patient's platelets, relative to control's. We suggest that
the combined impairment of prothrombin- and factor X-converting activities
in this patient is due to a defect in the mechanism by which
phosphatidylserine becomes exposed at the outer surface of stimulated
platelets.
Volume 65,
Issue 6,
pp. 1557-1561,
06/01/1985
Copyright © 1985 by The American Society of Hematology
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