Growth and cytogenetic characteristics of bone marrow colonies from
patients with 5q-syndrome
F Carbonell, H Heimpel, B Kubanek and TM Fliedner
Early erythroid precursor cells and myeloid progenitor cells (CFU-GM) from
four patients with 5q-syndrome were cultured in order to study the in vitro
growth patterns and to determine the clonal origin of this hematologic
disorder. Cultures of CFU-GM exhibited normal colony growth, while
erythroid progenitor cells demonstrated a marked decrease or absence of
colony growth. Chromosomal studies indicate the 5q- chromosome is present
in both hematopoietic progenitor cells, suggesting that the syndrome is an
acquired clonal disease arising from a pluripotent hematopoietic stem cell.
Follow-up cytogenetic studies reveal a decrease in the number of normal
metaphases. This finding is consistent with reports that emphasize the
slowly progressive nature of this malignant stem cell defect.
Volume 66,
Issue 2,
pp. 463-465,
08/01/1985
Copyright © 1985 by The American Society of Hematology
