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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nagasawa, T. Articles by Abe, T. Search for Related Content PubMed PubMed Citation Articles by Nagasawa, T. Articles by Abe, T. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Cell-mediated amegakaryocytic thrombocytopenia associated with systemic lupus erythematosus T Nagasawa, T Sakurai, H Kashiwagi and T Abe We studied a patient with a rare complication of amegakaryocytic thrombocytopenia (AMT) associated with systemic lupus erythematosus (SLE). To investigate the underlying pathogenesis of AMT, the effects of peripheral blood T cells and serum on human megakaryocyte progenitor cells were studied using in vitro coculture techniques. Mononuclear bone marrow cells (2 X 10(5) from normal donors produced 33.6 +/- 8.8 (n = 10) colony-forming unit-megakaryocytes (CFU-M) in our plasma clot system. When 2 X 10(5) of the patient's T cells were added to the culture system, the number of CFU-M decreased to only 3.5 +/- 0.6/2 X 10(5) bone marrow cells. No evidence of inhibitory effects was found by the addition of the patient's serum and complement to the culture system. The T cells stored at -80 degrees C on admission were also capable of suppressing autologous CFU-M after recovery from AMT. These results indicate that in vitro suppression of CFU-M from allogenic and autologous bone marrow cells by this patient's T cells provides an explanation for the pathogenesis of AMT associated with SLE. Volume 67, Issue 2, pp. 479-483, 02/01/1986 Copyright © 1986 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W Fureder, U Firbas, J L Nichol, J Pistillo, S Winkler, H Hiesberger, W R Sperr, J Smolen, and G Schett Serum thrombopoietin levels and anti-thrombopoietin antibodies in systemic lupus erythematosus Lupus, April 1, 2002; 11(4): 221 - 226. [Abstract] [PDF]

	Copyright © 1986 by American Society of Hematology         Online ISSN: 1528-0020