Trisomy 4 identifies a subset of acute nonlymphocytic leukemias
C Mecucci, A Van Orshoven, G Tricot, JL Michaux, A Delannoy and H Van den Berghe
We present four patients with acute nonlymphocytic leukemia, one M2 and
three M4 French-American-British (FAB) types and one patient with
refractory anemia with excess of blasts in transformation who at diagnosis
had trisomy of chromosome 4 as the primary karyotypic anomaly. This
chromosome anomaly probably defines a previously undescribed subset of
acute nonlymphoid leukemias. Hematologic characteristics commonly found in
these patients were dysplastic features of all bone marrow lineages,
suggesting that trisomy 4- associated disorders involve the early myeloid
hematopoietic stem cell.
Volume 67,
Issue 5,
pp. 1328-1332,
05/01/1986
Copyright © 1986 by The American Society of Hematology
