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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schaefer-Rego, K. Articles by Leibowitz, D. Search for Related Content PubMed PubMed Citation Articles by Schaefer-Rego, K. Articles by Leibowitz, D. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CML patients in blast crisis have breakpoints localized to a specific region of the BCR K Schaefer-Rego, H Dudek, D Popenoe, Z Arlin, JG Mears, A Bank and D Leibowitz Chronic myelogenous leukemia (CML) is associated with the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between chromosomes 9 and 22. This activates the abl oncogene by moving it from chromosome 9 and combining it with sequence located on chromosome 22. The new fusion gene, with chromosome 22 sequence at its 5' end and chromosome 9-abl sequence at its 3' end, generates a new messenger RNA (mRNA) and protein that are implicated in the pathogenesis of CML. The breakpoint near the c-abl locus on chromosome 9 can occur within a large area. In contrast, the breakpoints on chromosome 22 are concentrated within a 6 kilobase (kb) region termed the breakpoint cluster region (bcr). This study was designed to determine whether chronic-phase and blast crisis patients had identifiable differences in the structure of their Ph chromosomes. Restriction mapping of the chromosome 22 translocation breakpoints performed for 26 patients showed that the breakpoints of eight of the nine patients in blast crisis were in the 3' portion of the bcr, whereas the breakpoints in the 17 patients in the chronic phase were clustered in the 5' portion of the bcr. This suggests a strong correlation between a 3' bcr breakpoint and blast crisis in CML. Volume 70, Issue 2, pp. 448-455, 08/01/1987 Copyright © 1987 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Laurent, M. Talpaz, H. Kantarjian, and R. Kurzrock The BCR Gene and Philadelphia Chromosome-positive Leukemogenesis Cancer Res., March 1, 2001; 61(6): 2343 - 2355. [Full Text]

	Copyright © 1987 by American Society of Hematology         Online ISSN: 1528-0020