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The protooncogene c-fos is transcriptionally active in normal human granulocytes

K Heidorn, H Kreipe, HJ Radzun, R Muller and MR Parwaresch

Total cellular RNA of highly purified normal human blood cell populations was analyzed for the expression of the protooncogene c-fos, the cellular counterpart of the transforming FBJ virus. In marked contrast to previous findings based on in vitro studies with permanent leukemic cell lines, c-fos transcription was restricted to granulocytes. Neither blood monocytes nor blood lymphocytes or alveolar macrophages revealed detectable levels of c-fos transcription. Whereas this cellular oncogene is constitutively expressed in granulocytes, the monocytic cell line U-937 showed a transient c-fos transcription only after induction of differentiation. The contradiction between the results found in vivo and in vitro is discussed.

Volume 70, Issue 2, pp. 456-459, 08/01/1987
Copyright © 1987 by The American Society of Hematology


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