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The gene for protein S maps near the centromere of human chromosome 3
PC Watkins, R Eddy, Y Fukushima, MG Byers, EH Cohen, WR Dackowski, RM Wydro and TB Shows
Integrated Genetics, Inc, Framingham, MA 01701.
Two different mapping approaches were used to determine the human
chromosomal location of the gene for protein S. A human protein S cDNA was
used as a hybridization probe to analyze a panel of somatic cell hybrids
containing different human chromosomes. Cosegregation of protein S-specific
DNA restriction fragments with human chromosome 3 was observed. Three cell
hybrids containing only a portion of chromosome 3 were analyzed in order to
further localize protein S. Based on the somatic cell hybrid analysis,
protein S is assigned to a region of chromosome 3 that contains a small
part of the long arm and short arm of the chromosome including the
centromere (3p21----3q21). In situ hybridization of the protein S cDNA
probe to human metaphase chromosomes permitted a precise localization of
protein S to the region of chromosome 3 immediately surrounding the
centromere (3p11.1---- 3q11.2). Protein S is the first protein involved in
blood coagulation that has been mapped to human chromosome 3.
Volume 71,
Issue 1,
pp. 238-241,
01/01/1988
Copyright © 1988 by The American Society of Hematology
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