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Interleukin-6 enhances growth factor-dependent proliferation of the blast cells of acute myeloblastic leukemia

T Hoang, A Haman, O Goncalves, GG Wong and SC Clark

Clinical Research Institute of Montreal, Quebec.

The effects of recombinant interleukin-6 (IL-6) on the proliferation of blast precursors present in the peripheral blood of patients with acute myeloblastic leukemia (AML) was investigated. IL-6 had little effect by itself; however, it synergized with granulocyte macrophage colony- stimulating factor (GM-CSF) and interleukin-3 (IL-3) in the stimulation of AML blast colony formation. Responsiveness of blast progenitors to IL-6 was heterogeneous. On normal bone marrow cells the same synergy was observed on granulocyte and monocyte precursors (GM-CFC), while there was no significant effect on erythroid and multipotential precursors.

Volume 72, Issue 2, pp. 823-826, 08/01/1988
Copyright © 1988 by The American Society of Hematology


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