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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gonzalez-Sarmiento, R. Articles by Kersey, J. H. Search for Related Content PubMed PubMed Citation Articles by Gonzalez-Sarmiento, R. Articles by Kersey, J. H. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Usage of gamma chain variable regions in human acute lymphoblastic leukemias R Gonzalez-Sarmiento, JM Greenberg and JH Kersey Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis. The purpose of the present study was to evaluate the use of the variable regions of the T gamma rearranging gene of the second T cell receptor. Genomic DNA was extracted from leukemic cells of T and B precursor phenotypes and hybridized to probes that detect rearrangement of the V gamma regions. We present data showing that the V gamma use is nonrandom in acute lymphoblastic leukemias (ALLs). B precursor ALL rearranged the more 5' variable regions. The results obtained suggest that the T precursor leukemias more frequently rearrange the 3' V gamma regions. Two leukemias that expressed the gamma protein rearranged V gamma 8 and V gamma 9. Volume 72, Issue 6, pp. 2038-2041, 12/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020