|
|
 Previous Article | Table of Contents | Next Article 
Formation of C1s-C1-inhibitor, kallikrein-C1-inhibitor, and plasmin- alpha
2-plasmin-inhibitor complexes during cardiopulmonary bypass
YT Wachtfogel, PC Harpel, LH Edmunds and RW Colman
Thrombosis Research Center, Temple University School of Medicine,
Philadelphia, PA 19140.
Stimulation of platelets and neutrophils occurs during clinical
cardiopulmonary bypass. We investigated whether the classical complement,
contact, or fibrinolytic pathways are activated as potential sources of
neutrophil agonists. Using enzyme-linked immunosorbent "sandwich" assays
specific for C1s-C1-and kallikrein-C1- inhibitor complexes respectively, we
found that there was a modest increase in plasma levels of each complex
after clinical cardiopulmonary bypass was completed. The increased
concentration of enzyme-inhibitor complexes reverted to baseline within 24
hours. Since these complexes are cleared in vivo, we measured their
formation by assaying their plasma levels during in vitro simulated
extracorporeal circulation. Over a period of two hours, C1s-C1-inhibitor
complexes rose from a baseline of 2 +/- 1 nmol/L to 21 +/- 2 nmol/L, and
kallikrein-C1-inhibitor complexes rose from 2 +/- 1 nmol/L to 25 +/- 5
nmol/L. However, there was no evidence of either in vivo or in vitro
plasmin-alpha 2-plasmin-inhibitor complex formation. These results indicate
that the pathways of classical complement and contact activation, but
probably not fibrinolysis, may be associated with neutrophil activation
seen during clinical cardiopulmonary bypass.
Volume 73,
Issue 2,
pp. 468-471,
02/01/1989
Copyright © 1989 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
B. Marcheix, M. Carrier, C. Martel, M. Cossette, M. Pellerin, D. Bouchard, and L. P. Perrault
Effect of Pericardial Blood Processing on Postoperative Inflammation and the Complement Pathways
Ann. Thorac. Surg.,
February 1, 2008;
85(2):
530 - 535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. Hammon
Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation
Card. Surg. Adult,
January 1, 2008;
3(2008):
370 - 389.
[Full Text]
|
|
|
|
|
|
|
J. M. van den Goor, R. Nieuwland, P. M. Rutten, J. G. Tijssen, C. Hau, A. Sturk, L. Eijsman, and B. A. de Mol
Retransfusion of pericardial blood does not trigger systemic coagulation during cardiopulmonary bypass
Eur. J. Cardiothorac. Surg.,
June 1, 2007;
31(6):
1029 - 1036.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Baig, R. Nassar, D. M. Craig, G. Quick Jr, H. X. Jiang, M. M. Frank, A. J. Lodge, P. A.W. Anderson, and J. Jaggers
Complement Factor 1 Inhibitor Improves Cardiopulmonary Function in Neonatal Cardiopulmonary Bypass
Ann. Thorac. Surg.,
April 1, 2007;
83(4):
1477 - 1483.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Edmunds Jr and R. W. Colman
Thrombin During Cardiopulmonary Bypass
Ann. Thorac. Surg.,
December 1, 2006;
82(6):
2315 - 2322.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Kozik and J. S. Tweddell
Characterizing the Inflammatory Response to Cardiopulmonary Bypass in Children
Ann. Thorac. Surg.,
June 1, 2006;
81(6):
S2347 - S2354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hiramatsu, S. Homma, Y. Sato, S. Sato, K. Matsuzaki, O. Shigeta, and Y. Sakakibara
Nafamostat Preserves Neutrophil Deformability and Reduces Microaggregate Formation During Simulated Extracorporeal Circulation
Ann. Thorac. Surg.,
April 1, 2005;
79(4):
1326 - 1332.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. T. Lappegard, J. Riesenfeld, O.-L. Brekke, G. Bergseth, J. D. Lambris, and T. E. Mollnes
Differential Effect of Heparin Coating and Complement Inhibition on Artificial Surface-Induced Eicosanoid Production
Ann. Thorac. Surg.,
March 1, 2005;
79(3):
917 - 923.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. D. Rubens, H. Nathan, R. Labow, K. S. Williams, D. Wozny, J. Karsh, M. Ruel, and T. Mesana
Effects of Methylprednisolone and a Biocompatible Copolymer Circuit on Blood Activation During Cardiopulmonary Bypass
Ann. Thorac. Surg.,
February 1, 2005;
79(2):
655 - 665.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Shariat-Madar and A. H. Schmaier
Review: The plasma kallikrein/kinin and renin angiotensin systems in blood pressure regulation in sepsis
Innate Immunity,
February 1, 2004;
10(1):
3 - 13.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y. Kaminishi, Y. Hiramatsu, Y. Watanabe, Y. Yoshimura, and Y. Sakakibara
Effects of nafamostat mesilate and minimal-dose aprotinin on blood-foreign surface interactions in cardiopulmonary bypass
Ann. Thorac. Surg.,
February 1, 2004;
77(2):
644 - 650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Chong, C. R. Hampton, and E. D. Verrier
Microvascular Inflammatory Response in Cardiac Surgery
Seminars in Cardiothoracic and Vascular Anesthesia,
September 1, 2003;
7(3):
333 - 354.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. H. Edmunds Jr. and R. W. Colman
Extracorporeal Circulation: Thrombosis and Bleeding
Card. Surg. Adult,
January 1, 2003;
2(2003):
338 - 348.
[Full Text]
|
|
|
|
|
|
|
P. Menasche and L. H. Edmunds Jr.
Extracorporeal Circulation: The Inflammatory Response
Card. Surg. Adult,
January 1, 2003;
2(2003):
349 - 360.
[Full Text]
|
|
|
|
|
|
|
L H. Edmunds Jr
The evolution of cardiopulmonary bypass: lessons to be learned
Perfusion,
July 1, 2002;
17(4):
243 - 251.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Cugno, J. Nussberger, P. Biglioli, F. Alamanni, R. Coppola, and A. Agostoni
Increase of Bradykinin in Plasma of Patients Undergoing Cardiopulmonary Bypass : The Importance of Lung Exclusion
Chest,
December 1, 2001;
120(6):
1776 - 1782.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Campbell, B. Dixon, A. Kladis, M. Kemme, and J. D. Santamaria
Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 2001;
281(4):
R1059 - R1070.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. F. Mojcik and J. H. Levy
Aprotinin and the systemic inflammatory response after cardiopulmonary bypass
Ann. Thorac. Surg.,
February 1, 2001;
71(2):
745 - 754.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M.H. Khan, N. Gikakis, S. Miyamoto, A. K. Rao, S. L. Cooper, L. H. Edmunds Jr, and R. W. Colman
Aprotinin inhibits thrombin formation and monocyte tissue factor in simulated cardiopulmonary bypass
Ann. Thorac. Surg.,
August 1, 1999;
68(2):
473 - 478.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Philippou, S. J. Davidson, M. T. Mole, J. R. Pepper, J. F. Burman, and D. A. Lane
Two-Chain Factor VIIa Generated in the Pericardium During Surgery With Cardiopulmonary Bypass : Relationship to Increased Thrombin Generation and Heparin Concentration
Arterioscler Thromb Vasc Biol,
February 1, 1999;
19(2):
248 - 254.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Tofukuji, G. L. Stahl, A. Agah, C. Metais, M. Simons, and F. W. Sellke
ANTI-C5A MONOCLONAL ANTIBODY REDUCES CARDIOPULMONARY BYPASS AND CARDIOPLEGIA-INDUCED CORONARY ENDOTHELIAL DYSFUNCTION
J. Thorac. Cardiovasc. Surg.,
December 1, 1998;
116(6):
1060 - 1069.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Nilsson, R. Larsson, J. Hong, G. Elgue, K. N. Ekdahl, A. Sahu, and J. D. Lambris
Compstatin Inhibits Complement and Cellular Activation in Whole Blood in Two Models of Extracorporeal Circulation
Blood,
September 1, 1998;
92(5):
1661 - 1667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. F. Scott, H. Brandwein, J. Whitbread, and R. W. Colman
Lack of Clinically Significant Contact System Activation During Platelet Concentrate Filtration by Leukocyte Removal Filters
Blood,
July 15, 1998;
92(2):
616 - 622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Belougne-Malfattie, O. Aguejouf, L. Labrousse, and C. Doutremepuich
A Comparison of Heparin and New Anticoagulants for Cardiopulmonary Bypass Surgery
Clinical and Applied Thrombosis/Hemostasis,
April 1, 1998;
4(2):
118 - 125.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. J. Hunt, R. N. Parratt, H. C. Segal, S. Sheikh, P. Kallis, and M. Yacoub
Activation of Coagulation and Fibrinolysis During Cardiothoracic Operations
Ann. Thorac. Surg.,
March 1, 1998;
65(3):
712 - 718.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. W. Colman and A. H. Schmaier
Contact System: A Vascular Biology Modulator With Anticoagulant, Profibrinolytic, Antiadhesive, and Proinflammatory Attributes
Blood,
November 15, 1997;
90(10):
3819 - 3843.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. t. Velthuis, C. Baufreton, P. G. M. Jansen, C. M. Thijs, C. E. Hack, A. Sturk, C. R. H. Wildevuur, and D. Y. Loisance
HEPARIN COATING OF EXTRACORPOREAL CIRCUITS INHIBITS CONTACT ACTIVATION DURING CARDIAC OPERATIONS
J. Thorac. Cardiovasc. Surg.,
July 1, 1997;
114(1):
117 - 122.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Usui, M. Hiroura, M. Kawamura, M. Hibi, K. Yoshida, F. Murakami, Y. Tomita, H. Ooshima, and M. Murase
Nafamostat Mesilate Reduces Blood-Foreign Surface Reactions Similar to Biocompatible Materials
Ann. Thorac. Surg.,
November 1, 1996;
62(5):
1404 - 1411.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. J. Gu, J. de Haan, U. P. M. Brenken, W. J. de Boer, Jm. Prop, W. van Oeveren, and G. L. T. Group
CLOTTING AND FIBRINOLYTIC DISTURBANCE DURING LUNG TRANSPLANTATION: EFFECT OF LOW-DOSE APROTININ
J. Thorac. Cardiovasc. Surg.,
September 1, 1996;
112(3):
599 - 606.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. G. H. Speekenbrink, C. R. H. Wildevuur, A. Sturk, and L. Eijsman
LOW-DOSE AND HIGH-DOSE APROTININ IMPROVE HEMOSTASIS IN CORONARY OPERATIONS
J. Thorac. Cardiovasc. Surg.,
August 1, 1996;
112(2):
523 - 530.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. C. Deng, B. Dasch, M. Erren, T. Mollhoff, and H. H. Scheld
Impact of Left Ventricular Dysfunction on Cytokines, Hemodynamics, and Outcome in Bypass Grafting
Ann. Thorac. Surg.,
July 1, 1996;
62(1):
184 - 190.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. H. Chung, N. Gikakis, A. K. Rao, T. A. Drake, R. W. Colman, and L. H. Edmunds Jr
Pericardial Blood Activates the Extrinsic Coagulation Pathway During Clinical Cardiopulmonary Bypass
Circulation,
June 1, 1996;
93(11):
2014 - 2018.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Ali, J. Becket, J. Brannan, J. Fleming, and K. Taylor
The effect of high dose aprotinin therapy on the systemic inflammatory response in a porcine model of cardiopulmonary bypass
Perfusion,
May 1, 1996;
11(3):
278 - 280.
[PDF]
|
|
|
|
|
|
|
R. L. Korn, C. A. Fisher, E. R. Livingston, N. Stenach, S. J. Fishman, V. Jeevanandam, and V. P. Addonizio
THE EFFECTS OF CARMEDA BIOACTIVE SURFACE ON HUMAN BLOOD COMPONENTS DURING SIMULATED EXTRACORPOREAL CIRCULATION
J. Thorac. Cardiovasc. Surg.,
May 1, 1996;
111(5):
1073 - 1084.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. C. Gorman, N. P. Ziats, A. K. Rao, N. Gikakis, L. Sun, M. M. H. Khan, N. Stenach, S. Sapatnekar, V. Chouhan, J. H. Gorman III, et al.
SURFACE-BOUND HEPARIN FAILS TO REDUCE THROMBIN FORMATION DURING CLINICAL CARDIOPULMONARY BYPASS
J. Thorac. Cardiovasc. Surg.,
January 1, 1996;
111(1):
1 - 12.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
W. Tao, J. B. Zwischenberger, T. T. Nguyen, R. A. Vertrees, L. B. McDaniel, L. K. Nutt, D. N. Herndon, and G. C. Kramer
Gut mucosal ischemia during normothermic cardiopulmonary bypass results from blood flow redistribution and increased oxygen demand
J. Thorac. Cardiovasc. Surg.,
September 1, 1995;
110(3):
819 - 828.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. P. Mathew, C. S. Rinder, J. B. Tracey, L. A. Auszura, T. O'Connor, E. Davis, and B. R. Smith
Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass
J. Thorac. Cardiovasc. Surg.,
March 1, 1995;
109(3):
448 - 456.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. S. Rinder, D. Gaal, L. A. Student, and B. R. Smith
Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass
J. Thorac. Cardiovasc. Surg.,
January 1, 1994;
107(1):
280 - 288.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. Kesteven
Haemostatic changes during cardiopulmonary bypass
Perfusion,
January 1, 1990;
5(1_suppl):
9 - 19.
[PDF]
|
|
|
|
|
