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Interleukin-4 and interleukin-5 map to human chromosome 5 in a region
encoding growth factors and receptors and are deleted in myeloid leukemias
with a del(5q)
MM Le Beau, RS Lemons, R Espinosa , RA Larson, N Arai and JD Rowley
Department of Medicine, University of Chicago, IL 60637.
Interleukin-4 (IL-4) is a potent mediator of growth and differentiation of
cells of several hematopoietic lineages. Interleukin-5 (IL-5) is a
lineage-specific hematopoietic growth factor that stimulates the production
of eosinophils and eosinophil colonies from normal human bone marrow cells.
By using somatic cell hybrids and in situ chromosomal hybridization, we
localized the IL-4 and IL-5 genes to human chromosome 5 at bands q23-31, a
chromosomal region that is frequently deleted [del(5q)] in patients with
myeloid disorders. By in situ hybridization, the IL-4 and IL-5 genes were
found to be deleted in the 5q- chromosome of four patients with refractory
anemia (RA) or therapy-related acute nonlymphocytic leukemia (t-ANLL), who
had a del(5q). Thus a small segment of chromosome 5 contains IL-4, IL-5,
IL- 3, and GM-CSF as well as other genes such as CD14 and EGR1. Our
findings that each of these genes was deleted in the 5q- chromosome suggest
that loss of function of one or more of these genes may play an important
role in the pathogenesis of hematologic disorders associated with a
del(5q).
Volume 73,
Issue 3,
pp. 647-650,
02/15/1989
Copyright © 1989 by The American Society of Hematology
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