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A monoclonal antibody (LYP18) directed against the blood platelet
glycoprotein IIb/IIIa complex inhibits human melanoma growth in vivo
H Boukerche, O Berthier-Vergnes, M Bailly, JF Dore, LL Leung and JL McGregor
Faculte de Medecine Alexis Carrel, INSERM U218, Lyon, France.
A monoclonal antibody (MoAb) (LYP18), generated against human platelet
glycoprotein IIb/IIIa (GPIIb/IIIa), immuno-precipitated a IIb/IIIa-like GP
complex from a highly tumorigenic human melanoma cell line (M3Dau). The
M3Dau melanoma cells specifically bound 125I-labeled LYP18. To study the
biologic role of these IIb/IIIa-like glycoproteins, M3Dau melanoma cells
were incubated with LYP18 or a control MoAb directed against another
melanoma cell-surface antigen and implanted subcutaneously (SC) in nude
mice. LYP18 dramatically inhibited the growth of tumor in vivo. LYP18 was
not directly cytotoxic to the melanoma cells. These results demonstrate
that the IIb/IIIa-like GPs are present on melanoma cells and play a crucial
role in tumor cell growth. MoAbs directed against tumor cytoadhesive
receptors may represent a novel approach in tumor treatment.
Volume 74,
Issue 3,
pp. 909-912,
08/15/1989
Copyright © 1989 by The American Society of Hematology
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