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Malaria and red cell genetic defects
RL Nagel and EF Roth
Division of Hematology, Albert Einstein College of Medicine, Bronx, NY
10461.
The study of inherited RBC resistance to malaria has increased our
knowledge of the biochemistry and physiology of the host-parasite
interaction and suggested potential sites for therapeutic intervention.
Discovery by Jensen and Trager of the in vitro culture system for P
falciparum has facilitated research in this area. Known RBC defects may
affect invasion, growth, or merozoite liberation (Fig 1). Significant
advances made in understanding mechanisms underlying protection against
malaria should not obscure the fact that the data are far from complete.
More knowledge is needed about the influence of the erythrocyte
cytoskeleton on invasion and growth of parasites as well as the potential
role of phospholipids, erythrocyte enzymes other than G6PD, or other
metabolic products. Application of DNA analysis and recombinant technology
may have an increasing impact on study of the interaction of RBC defects
with malarial parasites.
Volume 74,
Issue 4,
pp. 1213-1221,
09/01/1989
Copyright © 1989 by The American Society of Hematology
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