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Graft failure after T-cell-depleted human leukocyte antigen identical
marrow transplants for leukemia: II. In vitro analyses of host effector
mechanisms
C Bordignon, CA Keever, TN Small, N Flomenberg, B Dupont, RJ O'Reilly and NA Kernan
Charles A. Dana Marrow Transplant Unit, Memorial Sloan-Kettering Cancer
Center, New York, NY 10021.
To identify mechanisms potentially contributing to graft failure, 19
leukemic recipients of T-cell-depleted marrow transplants who failed to
engraft following a transplant of HLA identical sibling marrow depleted of
T cells by soybean agglutinin (SBA) and sheep erythrocytes (E) were
evaluated. Peripheral blood mononuclear cells isolated at the time of
failure were consistently of host origin, bearing the phenotype of
suppressor T cells (CD3+, CD8+, Leu 7+). A direct cytolytic effect on
51Cr-labeled donor-derived target cells was not detected, a finding that
contrasts with the donor-specific cytotoxic host T lymphocytes that have
been regularly observed in patients rejecting HLA nonidentical SBA -E-
BMTs. However, these host T cells did exhibit a strong and specific
suppressive activity against the donor marrow CFU- GM in vitro.
Furthermore, in contrast to prior findings in durably engrafted recipients
of SBA -E- BMTs, the lymphocytes isolated prior to or at the time of graft
failure lacked natural killer surface antigen expression and effector
function.
Volume 74,
Issue 6,
pp. 2237-2243,
11/01/1989
Copyright © 1989 by The American Society of Hematology
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