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14q32 translocations are associated with mixed-lineage expression in
childhood acute leukemia
Y Hayashi, CH Pui, FG Behm, AH Fuchs, SC Raimondi, GR Kitchingman, J Mirro and DL Williams
Department of Pathology and Laboratory Medicine, St Jude Children's
Research Hospital, Memphis, TN 38105.
The frequency and characteristics of childhood acute leukemia with a 14q32
translocation [other than the t(8;14)(q24;q32)] were determined in 335
cases of newly diagnosed acute lymphoblastic leukemia (ALL) and 105 cases
of acute nonlymphoblastic leukemia (ANLL). Ten children, representing 2.3%
of the entire cohort, had this abnormality (1.5% of ALL patients and 4.8%
of ANLL patients). By French-American-British (FAB) criteria, 4 cases were
classified as L1, 1 as L2, 2 as M1, 1 as M2, and 2 as M5. Remarkably,
mixed-lineage expression was found in 6 of these 10 cases, but in only 21
of the other 430 cases without a 14q32 translocation (P less than .001).
Leukemic cells from 5 of these 6 cases (4 ANLL, and 1 ALL) coexpressed
CD13, a myeloid-associated antigen, and CD2, a T-cell-associated antigen;
blasts from the sixth case (ALL) coexpressed CD13 and CD19, a
B-lineage-associated antigen. Thus, in addition to the well-described 11q23
translocations and t(9;22), 14q32 translocations also appear to be
associated with mixed lineage antigen expression. Break-points of the
reciprocal chromosomes from chromosome 14 were identified in five of these
cases: 1q23, 6q23- q25, 7p15, 8q11, and 12q13. Of the four mixed-lineage
cases that were tested, none showed rearrangement of the immunoglobulin
heavy chain (IgH) gene. This suggests that the 14q32 breakpoint does not
involve the IgH gene and that an unidentified important gene may reside on
14q32.
Volume 76,
Issue 1,
pp. 150-156,
07/01/1990
Copyright © 1990 by The American Society of Hematology
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