|
|
 Previous Article | Table of Contents | Next Article 
NB4, a maturation inducible cell line with t(15;17) marker isolated from a
human acute promyelocytic leukemia (M3)
M Lanotte, V Martin-Thouvenin, S Najman, P Balerini, F Valensi and R Berger
INSERM U-301, SDI No 15954.1 CNRS, Centre Hayem, Paris, France.
Acute promyelocytic leukemia (APL) is a well-defined entity among acute
leukemia, cytogenetically characterized by a t(15;17) (q22;q11-12)
translocation. In vitro and in vivo studies suggest that all-trans retinoic
acid (RA) treatment restores cell maturation. We have isolated the first
permanent cell line with t(15;17), derived from the marrow of a patient
with APL in relapse. The establishment of the cell line, its morphologic,
karyotypic, and immunohistochemical features are reported. RA induced cell
line maturation. Cells strongly expressed myeloid markers, but also some
T-cell markers. Additional karyotypic abnormalities, a 12p rearrangement
and the possible presence of a homogeneous staining region (HSR) on 19q+
are discussed both in relation to T-cell (CD2, CD4) and monocyte (CD9)
markers, and to the acquired cell growth autonomy. The cell line represents
a remarkable tool for biomolecular studies.
Volume 77,
Issue 5,
pp. 1080-1086,
03/01/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Zhang, L.-P. Song, Y. Huang, Q. Zhao, K.-W. Zhao, and G.-Q. Chen
Accumulation of hypoxia-inducible factor-1{alpha} protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid
Haematologica,
October 1, 2008;
93(10):
1480 - 1487.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Ao, S.-X. Liu, M.-S. Yang, C.-C. Fong, H. An, and J. Cao
Acrylamide-induced molecular mutation spectra at HPRT locus in human promyelocytic leukaemia HL-60 and NB4 cell lines
Mutagenesis,
July 1, 2008;
23(4):
309 - 315.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Si and S. J. Collins
Activated Ca2+/Calmodulin-Dependent Protein Kinase II{gamma} Is a Critical Regulator of Myeloid Leukemia Cell Proliferation
Cancer Res.,
May 15, 2008;
68(10):
3733 - 3742.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Wang, G.-B. Zhou, P. Liu, J.-H. Song, Y. Liang, X.-J. Yan, F. Xu, B.-S. Wang, J.-H. Mao, Z.-X. Shen, et al.
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
PNAS,
March 25, 2008;
105(12):
4826 - 4831.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rosa, M. Ballarino, A. Sorrentino, O. Sthandier, F. G. De Angelis, M. Marchioni, B. Masella, A. Guarini, A. Fatica, C. Peschle, et al.
The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation
PNAS,
December 11, 2007;
104(50):
19849 - 19854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Miranda, R. L. Redner, and D. E. Johnson
Inhibition of Src family kinases enhances retinoic acid induced gene expression and myeloid differentiation
Mol. Cancer Ther.,
December 1, 2007;
6(12):
3081 - 3090.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nakazato, M. Sagawa, K. Yamato, M. Xian, T. Yamamoto, M. Suematsu, Y. Ikeda, and M. Kizaki
Myeloperoxidase Is a Key Regulator of Oxidative Stress Mediated Apoptosis in Myeloid Leukemic Cells
Clin. Cancer Res.,
September 15, 2007;
13(18):
5436 - 5445.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. P. Ng, D. S. Nin, J. H. Fong, D. Venkataraman, C.-S. Chen, and M. Khan
Therapeutic targeting of nuclear receptor corepressor misfolding in acute promyelocytic leukemia cells with genistein
Mol. Cancer Ther.,
August 1, 2007;
6(8):
2240 - 2248.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hattori, X. Zhang, Y. Jia, K. K. Subramanian, H. Jo, F. Loison, P. E. Newburger, and H. R. Luo
RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells
Blood,
July 15, 2007;
110(2):
640 - 650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. S. Dbaibo, Y. Kfoury, N. Darwiche, S. Panjarian, L. Kozhaya, R. Nasr, M. Abdallah, O. Hermine, M. El-Sabban, H. de The, et al.
Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity
Haematologica,
June 1, 2007;
92(6):
753 - 762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rizzi, M. P. Tschan, C. Britschgi, A. Britschgi, B. Hugli, T. J. Grob, N. Leupin, B. U. Mueller, H.-U. Simon, A. Ziemiecki, et al.
The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells
J. Leukoc. Biol.,
June 1, 2007;
81(6):
1599 - 1608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Tabe, L. Jin, Y. Tsutsumi-Ishii, Y. Xu, T. McQueen, W. Priebe, G. B. Mills, A. Ohsaka, I. Nagaoka, M. Andreeff, et al.
Activation of Integrin-Linked Kinase Is a Critical Prosurvival Pathway Induced in Leukemic Cells by Bone Marrow-Derived Stromal Cells
Cancer Res.,
January 15, 2007;
67(2):
684 - 694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kitareewan, B. D. Roebuck, E. Demidenko, R. D. Sloboda, and E. Dmitrovsky
Lysosomes and Trivalent Arsenic Treatment in Acute Promyelocytic Leukemia
J Natl Cancer Inst,
January 3, 2007;
99(1):
41 - 52.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Germain, P. Chambon, G. Eichele, R. M. Evans, M. A. Lazar, M. Leid, A. R. De Lera, R. Lotan, D. J. Mangelsdorf, and H. Gronemeyer
International Union of Pharmacology. LX. Retinoic Acid Receptors
Pharmacol. Rev.,
December 1, 2006;
58(4):
712 - 725.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Zeng, I. J. Samudio, M. Munsell, J. An, Z. Huang, E. Estey, M. Andreeff, and M. Konopleva
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
Mol. Cancer Ther.,
December 1, 2006;
5(12):
3113 - 3121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Trivedi, S. C. Zhang, A. B. Castoreno, W. Stockinger, E. C. Shieh, J. M. Vyas, E.-M. Frickel, and A. Nohturfft
Immunoglobulin G signaling activates lysosome/phagosome docking
PNAS,
November 28, 2006;
103(48):
18226 - 18231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Xiao, D. Li, H.-Q. Zhu, M.-G. Song, X.-R. Pan, P.-M. Jia, L.-L. Peng, A.-X. Dou, G.-Q. Chen, S.-J. Chen, et al.
RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins
PNAS,
October 31, 2006;
103(44):
16448 - 16453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Balajthy, K. Csomos, G. Vamosi, A. Szanto, M. Lanotte, and L. Fesus
Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions
Blood,
September 15, 2006;
108(6):
2045 - 2054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lennartsson, K. Vidovic, M. B. Pass, J. B. Cowland, and U. Gullberg
All-trans retinoic acid-induced expression of bactericidal/permeability-increasing protein (BPI) in human myeloid cells correlates to binding of C/EBP{beta} and C/EBP{epsilon} to the BPI promoter
J. Leukoc. Biol.,
July 1, 2006;
80(1):
196 - 203.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-L. Wu, C. Dudognon, E. Nguyen, J. Hillion, F. Pendino, I. Tarkanyi, J. Aradi, M. Lanotte, J.-H. Tong, G.-Q. Chen, et al.
Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths
J. Cell Sci.,
July 1, 2006;
119(13):
2797 - 2806.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Robert, L. Delva, N. Balitrand, S. Nahajevszky, T. Masszi, C. Chomienne, and B. Papp
Apoptosis Induction by Retinoids in Eosinophilic Leukemia Cells: Implication of Retinoic Acid Receptor-{alpha} Signaling in All-Trans-Retinoic Acid Hypersensitivity.
Cancer Res.,
June 15, 2006;
66(12):
6336 - 6344.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Luciani, D. Depetris, Y. Usson, C. Metzler-Guillemain, C. Mignon-Ravix, M. J. Mitchell, A. Megarbane, P. Sarda, H. Sirma, A. Moncla, et al.
PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase
J. Cell Sci.,
June 15, 2006;
119(12):
2518 - 2531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-F. Che, C.-L. Zheng, S. Owatari, M. Mutoh, T. Gotanda, H.-C. Jeung, T. Furukawa, R. Ikeda, M. Yamamoto, M. Haraguchi, et al.
Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines
Blood,
June 15, 2006;
107(12):
4880 - 4887.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yaneva, S. Kippenberger, N. Wang, Q. Su, M. McGarvey, A. Nazarian, L. Lacomis, H. Erdjument-Bromage, and P. Tempst
PU.1 and a TTTAAA Element in the Myeloid Defensin-1 Promoter Create an Operational TATA Box That Can Impose Cell Specificity onto TFIID Function.
J. Immunol.,
June 1, 2006;
176(11):
6906 - 6917.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. U. Mueller, T. Pabst, J. Fos, V. Petkovic, M. F. Fey, N. Asou, U. Buergi, and D. G. Tenen
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression
Blood,
April 15, 2006;
107(8):
3330 - 3338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Zeng, I. J. Samudio, W. Zhang, Z. Estrov, H. Pelicano, D. Harris, O. Frolova, N. Hail Jr., W. Chen, S. M. Kornblau, et al.
Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia.
Cancer Res.,
April 1, 2006;
66(7):
3737 - 3746.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Tabe, M. Konopleva, R. Contractor, M. Munsell, W. D. Schober, L. Jin, Y. Tsutsumi-Ishii, I. Nagaoka, J. Igari, and M. Andreeff
Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells
Blood,
February 15, 2006;
107(4):
1546 - 1554.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Gale, R. Hills, A. R. Pizzey, P. D. Kottaridis, D. Swirsky, A. F. Gilkes, E. Nugent, K. I. Mills, K. Wheatley, E. Solomon, et al.
Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia
Blood,
December 1, 2005;
106(12):
3768 - 3776.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Altucci, A. Rossin, O. Hirsch, A. Nebbioso, D. Vitoux, E. Wilhelm, F. Guidez, M. De Simone, E. M. Schiavone, D. Grimwade, et al.
Rexinoid-Triggered Differentiation and Tumor-Selective Apoptosis of Acute Myeloid Leukemia by Protein Kinase A-Mediated Desubordination of Retinoid X Receptor
Cancer Res.,
October 1, 2005;
65(19):
8754 - 8765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Saumet, M. B. Slimane, M. Lanotte, J. Lawler, and V. Dubernard
Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/{alpha}v{beta}3 in promyelocytic leukemia NB4 cells
Blood,
July 15, 2005;
106(2):
658 - 667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Ramos, C. Fernandez, D. Amran, P. Sancho, E. de Blas, and P. Aller
Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells
Blood,
May 15, 2005;
105(10):
4013 - 4020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Gaines, J. Chi, and N. Berliner
Heterogeneity of functional responses in differentiated myeloid cell lines reveals EPRO cells as a valid model of murine neutrophil functional activation
J. Leukoc. Biol.,
May 1, 2005;
77(5):
669 - 679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Denis, A. Benecke, Y. Di Gioia, I. P. Touw, Y. E. Cayre, and P. G. Lutz
PRAM-1 Potentiates Arsenic Trioxide-induced JNK Activation
J. Biol. Chem.,
March 11, 2005;
280(10):
9043 - 9048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Matsuda, A. Almasan, M. Tomita, J.-n. Uchihara, M. Masuda, K. Ohshiro, N. Takasu, H. Yagita, T. Ohta, and N. Mori
Resistance to Apo2 Ligand (Apo2L)/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Apoptosis and Constitutive Expression of Apo2L/TRAIL in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines
J. Virol.,
February 1, 2005;
79(3):
1367 - 1378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. Lane and T. J. Ley
Neutrophil Elastase Is Important for PML-Retinoic Acid Receptor {alpha} Activities in Early Myeloid Cells
Mol. Cell. Biol.,
January 1, 2005;
25(1):
23 - 33.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Fleck, S. Romero-Steiner, and M. H. Nahm
Use of HL-60 Cell Line To Measure Opsonic Capacity of Pneumococcal Antibodies
Clin. Vaccine Immunol.,
January 1, 2005;
12(1):
19 - 27.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nouzova, N. Holtan, M. M. Oshiro, R. B. Isett, J. L. Munoz-Rodriguez, A. F. List, M. L. Narro, S. J. Miller, N. C. Merchant, and B. W. Futscher
Epigenomic Changes during Leukemia Cell Differentiation: Analysis of Histone Acetylation and Cytosine Methylation Using CpG Island Microarrays
J. Pharmacol. Exp. Ther.,
December 1, 2004;
311(3):
968 - 981.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Konopleva, T. Tsao, Z. Estrov, R.-m. Lee, R.-Y. Wang, C. E. Jackson, T. McQueen, G. Monaco, M. Munsell, J. Belmont, et al.
The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Caspase-Dependent and -Independent Apoptosis in Acute Myelogenous Leukemia
Cancer Res.,
November 1, 2004;
64(21):
7927 - 7935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Parrella, M. Gianni', V. Cecconi, E. Nigro, M. M. Barzago, A. Rambaldi, C. Rochette-Egly, M. Terao, and E. Garattini
Phosphodiesterase IV Inhibition by Piclamilast Potentiates the Cytodifferentiating Action of Retinoids in Myeloid Leukemia Cells: CROSS-TALK BETWEEN THE cAMP AND THE RETINOIC ACID SIGNALING PATHWAYS
J. Biol. Chem.,
October 1, 2004;
279(40):
42026 - 42040.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Soda, K. Tani, Y. Bai, M. Saiki, M. Chen, K. Izawa, S. Kobayashi, S. Takahashi, K. Uchimaru, T. Kuwabara, et al.
A novel maxizyme vector targeting a bcr-abl fusion gene induced specific cell death in Philadelphia chromosome-positive acute lymphoblastic leukemia
Blood,
July 15, 2004;
104(2):
356 - 363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Alberich Jorda, N. Rayman, M. Tas, S. E. Verbakel, N. Battista, K. van Lom, B. Lowenberg, M. Maccarrone, and R. Delwel
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner
Blood,
July 15, 2004;
104(2):
526 - 534.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ito, T. Nakazato, A. Murakami, K. Yamato, Y. Miyakawa, T. Yamada, N. Hozumi, H. Ohigashi, Y. Ikeda, and M. Kizaki
Induction of Apoptosis in Human Myeloid Leukemic Cells by 1'-Acetoxychavicol Acetate through a Mitochondrial- and Fas-Mediated Dual Mechanism
Clin. Cancer Res.,
March 15, 2004;
10(6):
2120 - 2130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
