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Clonal analysis of T-cell deficiencies in autotransplant recipients
RA Miller, J Daley, R Ghalie and H Kaizer
Department of Pathology, Boston University School of Medicine, MA.
We have used limiting dilution culture methods to determine the frequency
of mitogen-responsive T cells in peripheral blood of patients after bone
marrow autotransplantation, and have compared their responsiveness to that
of allotransplant recipients and normal controls. Autotransplant patients
were found to have low responder cell frequencies in tests for
lymphokine-secreting helper function, and for IL-2 dependent proliferator
and cytotoxic function. Multiple regression analysis showed that function
was lower in autotransplant patients than in allorecipients, and lower in
male patients for all three functional assays. Patients with clinically
significant infection tended to have lower proliferative function in both
transplant groups and lower cytotoxic function in the allotransplant
population. Graft-versus-host disease was associated with lower T-cell
function, but was present only in the allotransplant group; therefore, it
cannot account for the even lower levels of function observed in the
autotransplant population. Because we observe deficits in T-cell
regeneration in autotransplant recipients that are even more severe than in
allorecipients, we postulate that cellular immunodeficiency after bone
marrow transplantation may reflect limitations in thymic-dependent
repopulation rather than an effect of genetic disparity between host and
donor (eg, clinical or subclinical graft-versus-host).
Volume 77,
Issue 8,
pp. 1845-1850,
04/15/1991
Copyright © 1991 by The American Society of Hematology
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