|
|
 Previous Article | Table of Contents | Next Article 
Adhesive functions of platelets lacking glycoprotein IV (CD36)
NN Tandon, CF Ockenhouse, NJ Greco and GA Jamieson
American Red Cross, Cell Biology Laboratory, Rockville, MD 20855.
Glycoprotein IV (GPIV; CD36 or GPIIIb) is a cell surface glycoprotein that
has been proposed as mediating a number of physiologically important
processes such as the adhesion of platelets to thrombospondin (TSP) and
collagen, the cytoadherence of Plasmodium falciparum-infected erythrocytes,
and the TSP-dependent interaction of monocytes with platelets and
macrophages. Because platelets of the Naka-negative phenotype have recently
been shown to lack detectable GPIV, their availability offered the
opportunity to test directly these hypotheses regarding its adhesive
functions. It has been found that Naka-negative platelets and monocytes do
not support cytoadherence of P falciparum- infected erythrocytes.
Naka-negative platelets are deficient in the initial stages of their
adhesion to fibrillar collagen and this defect is most marked under
Mg(2+)-free conditions. Finally, the ability of Naka-negative platelets to
bind TSP before or after activation is unimpaired as compared with normal
controls. These results do not support a role for GPIV as the TSP receptor.
Volume 78,
Issue 11,
pp. 2809-2813,
12/01/1991
Copyright © 1991 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. S. Isenberg, M. J. Romeo, C. Yu, C. K. Yu, K. Nghiem, J. Monsale, M. E. Rick, D. A. Wink, W. A. Frazier, and D. D. Roberts
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling
Blood,
January 15, 2008;
111(2):
613 - 623.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Marsche, R. Zimmermann, S. Horiuchi, N. N. Tandon, W. Sattler, and E. Malle
Class B Scavenger Receptors CD36 and SR-BI Are Receptors for Hypochlorite-modified Low Density Lipoprotein
J. Biol. Chem.,
November 28, 2003;
278(48):
47562 - 47570.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Austin, J. E. B. Fox, G. H. Werstuck, A. R. Stafford, D. E. Bulman, G. Y. Dally, C. A. Ackerley, J. I. Weitz, and P. N. Ray
Identification of Dp71 Isoforms in the Platelet Membrane Cytoskeleton. POTENTIAL ROLE IN THROMBIN-MEDIATED PLATELET ADHESION
J. Biol. Chem.,
November 27, 2002;
277(49):
47106 - 47113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nakamura, G. A. Jamieson, M. Okuma, J.-i. Kambayashi, and N. N. Tandon
Platelet Adhesion to Native Type I Collagen Fibrils. ROLE OF GPVI IN DIVALENT CATION-DEPENDENT AND -INDEPENDENT ADHESION AND THROMBOXANE A2 GENERATION
J. Biol. Chem.,
February 20, 1998;
273(8):
4338 - 4344.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Dubernard, B. B. Arbeille, M. B. Lemesle, and C. Legrand
Evidence for an {alpha}-Granular Pool of the Cytoskeletal Protein {alpha}-Actinin in Human Platelets That Redistributes With the Adhesive Glycoprotein Thrombospondin-1 During the Exocytotic Process
Arterioscler Thromb Vasc Biol,
October 1, 1997;
17(10):
2293 - 2305.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Diaz-Ricart, N. N. Tandon, G. Gomez-Ortiz, M. Carretero, G. Escolar, A. Ordinas, and G.A. Jamieson
Antibodies to CD36 (GPIV) Inhibit Platelet Adhesion to Subendothelial Surfaces Under Flow Conditions
Arterioscler Thromb Vasc Biol,
July 1, 1996;
16(7):
883 - 888.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. F. Thorne, J. F. Marshall, D. R. Shafren, P. G. Gibson, I. R. Hart, and G. F. Burns
The Integrins alpha 3beta 1 and alpha 6beta 1 Physically and Functionally Associate with CD36 in Human Melanoma Cells. REQUIREMENT FOR THE EXTRACELLULAR DOMAIN OF CD36
J. Biol. Chem.,
November 3, 2000;
275(45):
35264 - 35275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
