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Anemia and mast cell depletion in mutant rats that are homozygous at "white
spotting (Ws)" locus
Y Niwa, T Kasugai, K Ohno, M Morimoto, M Yamazaki, K Dohmae, Y Nishimune, K Kondo and Y Kitamura
Laboratory of Experimental Animals, Yagi Memorial Park, Kani-gun, Japan.
Mice possessing two mutant alleles at the W or Sl locus are anemic and
deficient in mast cells. These mouse mutants have black eyes and white
hair. Because homozygous mutant rats at the newly found white spotting (Ws)
locus were also black-eyed whites, the numbers of erythrocytes and mast
cells were examined. Suckling Ws/Ws rats showed a severe macrocytic anemia
and were deficient in mast cells. When bone marrow cells of normal (+/+)
control or Ws/Ws rats were injected into C3H/He mice that had received
cyclophosphamide injection and whole-body irradiation, remarkable
erythropoiesis occurred in the spleen of +/+ marrow recipients but not in
the spleen of Ws/Ws marrow recipients. When skin pieces of Ws/Ws embryos
were grafted under the kidney capsule of nude athymic rats, mast cells did
develop in the grafted skin tissues. Therefore, the anemia and mast cell
deficiency of Ws/Ws rats were attributed to a defect of precursors of
erythrocytes and mast cells. Because the magnitude of the anemia decreased
and that of the mast cell deficiency increased in adult Ws/Ws rats, this
mutant is potentially useful for investigations about differentiation and
function of mast cells.
Volume 78,
Issue 8,
pp. 1936-1941,
10/15/1991
Copyright © 1991 by The American Society of Hematology
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