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Erythroid-restricted expression of homeobox genes of the human HOX 2 locus
CH Mathews, K Detmer, E Boncinelli, HJ Lawrence and C Largman
Veterans Affairs Medical Center, Martinez, CA 94553.
We have previously reported that certain members of the HOX 1 and HOX 2
clusters of class 1 homeobox-containing genes showed lineage-restricted
patterns of expression in a small series of human hematopoietic cell lines.
We now report on the expression patterns of the entire HOX 2 cluster,
consisting of nine homeobox genes, in a broad survey of leukemic cell lines
of different phenotypes. The most striking observation is that all but one
of the HOX 2 genes are consistently expressed in cells with erythroid
character and/or potential, but, with rare exception, not in cells with
myelomonocytic or T- or B-lymphoid phenotype. By contrast, several genes of
the HOX 1 and 3 loci are not expressed in erythroid lines. Within erythroid
cell lines, many of the HOX 2 genes are expressed as multiple transcripts.
Expression of some HOX 2 genes is detectable in normal human marrow. These
data show that in human hematopoietic cell lines HOX 2 homeobox gene
expression is largely restricted to cells of erythroid phenotype and
suggest that these genes play a role in erythropoiesis.
Volume 78,
Issue 9,
pp. 2248-2252,
11/01/1991
Copyright © 1991 by The American Society of Hematology
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