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Translocations involving band 3q27 and Ig gene regions in non-Hodgkin's
lymphoma [see comments]
C Bastard, H Tilly, B Lenormand, C Bigorgne, D Boulet, A Kunlin, M Monconduit and H Piguet
Department of Cytogenetics, Centre Regional de Transfusion Sanguine,
Bois-Guillaume, France.
We report a series of 20 non-Hodgkin's lymphomas (NHL) in which cytogenetic
analysis showed a translocation involving band 3q27 and the site of one of
the three Ig genes (14q32, 2p12, 22q11) in the neoplastic cells. These
cases were found in a series of 319 patients with clonal chromosomal
abnormalities studied over a 7-year period. Fourteen patients had diffuse
lymphoma, mainly of large cell type and the remaining six were follicular
lymphomas. All cases studied were of B-cell phenotype. A t(3;14)(q27;q32)
was commonest, found in 15 patients (4.7%), with the two variant
translocations, t(3;22)(q27;q11) and t(2;3)(p12;q27), being found in three
and two patients, respectively. Additional chromosomal defects were present
in most patients, but two patients had this type of translocation as the
sole abnormality. These results indicate that translocations involving band
3q27 and Ig genes are not uncommon, and suggest that a novel oncogene,
located at band 3q27, may be implicated in B-cell NHL.
Volume 79,
Issue 10,
pp. 2527-2531,
05/15/1992
Copyright © 1992 by The American Society of Hematology
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