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Origin of anti-idiotypic activity against anti-factor VIII autoantibodies
in pools of normal human immunoglobulin G (IVIg)
G Dietrich, M Algiman, Y Sultan, UE Nydegger and MD Kazatchkine
INSERM U28, Hopital Broussais, Paris, France.
Therapeutic preparations of polyspecific IgG obtained from plasma pools of
a large number of normal donors (IVIg) express anti-idiotypic activity
against a wide spectrum of natural and disease-associated autoantibodies.
The present study investigated the origin of anti- idiotypic activity
against autoantibodies to factor VIII. The neutralizing activity of pools
of IgG against patients' anti-factor VIII autoantibodies was not influenced
by the presence of individuals with natural anti-factor VIII antibodies
among donors contributing to the pool. A higher frequency of neutralizing
antibodies against anti- factor VIII autoantibodies was found in aged
donors as compared with young adults and in pools of IgG from multiparous
women as compared with IgG from random donors. Pooling IgG from several
donors synergistically enhanced the inhibitory activity of the pools. Thus,
a neutralizing activity against anti-factor VIII autoantibodies was
detected in pools of IgG of as few as two to four donors of whom
individually tested IgG did not exhibit inhibitory activity against
anti-factor VIII autoantibodies. These observations suggest that aged
donors and multiparous women may be privileged sources for the anti-
idiotypic activity of IVIg against autoantibodies and emphasize that the
expression of anti-idiotypic activity in IVIg results from a synergistic
participation of anti-idiotypes from each donor contributing to the pool.
Volume 79,
Issue 11,
pp. 2946-2951,
06/01/1992
Copyright © 1992 by The American Society of Hematology
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