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The low risk of hepatitis C virus transmission among sexual partners of
hepatitis C-infected hemophilic males: an international, multicenter study
DB Brettler, PM Mannucci, A Gringeri, JE Rasko, AD Forsberg, MG Rumi, RJ Garsia, KA Rickard and M Colombo
Department of Medicine, Medical Center of Central Massachusetts, Worcester
01605.
To study the transmission rate of hepatitis C virus (HCV) in the female
sexual partners of antibody-positive hemophilic males, 106 partners from
three hemophilia centers located in Europe, America, and Australia were
tested for HCV seropositivity using a first-generation enzyme- linked
immunosorbent assay (ELISA-1) and, subsequently, a second- generation ELISA
(ELISA-2) and a supplemental recombinant immunoblot assay. Additionally,
the cohort was tested for the presence of antibody to the human
immunodeficiency virus type-1 and hepatitis B virus markers. No female
partner was HCV antibody-positive using the ELISA-1 test, whereas five were
seropositive by the ELISA-2 test. Three of these five female partners were
seropositive on the supplemental test, the remaining two having
indeterminate results, for an overall prevalence of 2.7%. Thus, even with
the use of sensitive testing, the prevalence of HCV infection remains low
in this cohort, showing that the efficiency of heterosexual transmission of
HCV is poor.
Volume 80,
Issue 2,
pp. 540-543,
07/15/1992
Copyright © 1992 by The American Society of Hematology
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