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The human Kell blood group gene maps to chromosome 7q33 and its expression
is restricted to erythroid cells
S Lee, ED Zambas, WL Marsh and CM Redman
Lindsley F. Kimball Research Institute, New York Blood Center, NY 10021.
The Kell blood group is one of the major antigenic systems in human red
blood cells. To determine the location of the Kell gene on human
chromosomes, panels containing genomic DNA of human-hamster somatic cell
hybrids were hybridized with radiolabeled cDNA probe specific for the Kell
locus. Only the samples containing DNA from chromosome 7 gave positive
hybridization signals. In situ hybridization analysis, using genomic clones
isolated with the cDNA, localized the KEL gene to 7q33. Northern blot
analysis of poly(A)+ RNA from human brain, kidney, lung, fetal and adult
liver, and bone marrow showed that Kell transcripts were only present in
fetal liver and bone marrow. This indicates that the Kell protein, which
carries the Kell antigens, may only be expressed in erythroid tissues.
Volume 81,
Issue 10,
pp. 2804-2809,
05/15/1993
Copyright © 1993 by The American Society of Hematology
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