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CD34 expression is regulated reciprocally with adhesion molecules in
vascular endothelial cells in vitro
D Delia, MG Lampugnani, M Resnati, E Dejana, A Aiello, E Fontanella, D Soligo, MA Pierotti and MF Greaves
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Freshly cultured vascular endothelial cells express the CD34 antigen in a
diffuse cell surface pattern with some concentration on microvilli.
Expression is downregulated with proliferation in continuous culture and
undetectable after nine population doublings but can be maintained by
restraining cell proliferation and promoting cell contact. Expression of
CD34 at the antigen and mRNA levels on early passage cells is rapidly
downregulated by interleukin-1 beta (IL-1 beta), interferon-gamma
(INF-gamma), and tumor necrosis factor-alpha (TNF- alpha) under conditions
in which these ligands upregulate the adhesion molecules: endothelial
leukocyte adhesion molecule 1 (ELAM-1) and intracellular adhesion molecule
1 (ICAM-1). This reciprocal pattern of expression and the topographic
distribution of CD34 molecules on the lumenal interdigitated microprocesses
of adjacent endothelial cells in vivo suggest that CD34 might have a
negative modulating role on adhesion functions of endothelia.
Volume 81,
Issue 4,
pp. 1001-1008,
02/15/1993
Copyright © 1993 by The American Society of Hematology
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