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Cell-type-specific transactivation of the parathyroid hormone-related
protein gene promoter by the human T-cell leukemia virus type I (HTLV- I)
tax and HTLV-II tax proteins
E Ejima, JD Rosenblatt, M Massari, E Quan, D Stephens, CA Rosen and D Prager
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
The human T-cell leukemia virus type I (HTLV-I) and HTLV-II Tax proteins
are potent transactivators of viral and cellular gene expression. Using
deletion mutants, the downstream parathyroid hormone- related protein
(PTHrP) promoter is shown to be responsive to both HTLV- I and HTLV-II Tax
as well as the AP1/c-jun proto-oncogene. Transactivation of PTHrP by Tax
was seen in T cells but not in B-cell lines or fibroblasts. A carboxy
terminal Tax deletion mutant was deficient in transactivation of both the
PTHrP and IL2R alpha promoters but not the HTLV-I long terminal repeat
(LTR). Exogenous provision of NFkB rescued IL2R alpha expression but not
the PTHrP promoter. Thus, HTLV-I Tax, HTLV-II Tax, and c-jun transactivate
PTHrP and may contribute to the pathogenesis of hypercalcemia in adult
T-cell leukemia.
Volume 81,
Issue 4,
pp. 1017-1024,
02/15/1993
Copyright © 1993 by The American Society of Hematology
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