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In vitro infection of human macrophages with human T-cell leukemia virus
type 1
T de Revel, A Mabondzo, G Gras, B Delord, P Roques, F Boussin, Y Neveux, M Bahuau, HJ Fleury and D Dormont
Laboratoire de Neuropathologie experimentale et Neurovirologie, CRSSA,
DSV/DPTE, Commissariat a l'Energie Atomique, Fontenay aux-Roses, France.
The tropism of the human T-cell leukemia virus type 1 (HTLV-1) for the
cells of monocyte-macrophage lineage was evaluated by the coculture of
blood monocyte-derived macrophages, with irradiated cells of HTLV-1
producing cell lines MT2 or C91/PL. The susceptibility to HTLV-1 was
assessed by the detection of viral DNA using the polymerase chain reaction
method. HTLV-1 gene expression in the cells was detected using in situ
hybridization and by immunofluorescent staining of viral antigen. The
presence of type C virus-like particles detected by electron microscopy and
the ability to infect normal cord blood lymphocytes demonstrated that the
infected macrophages produced infectious virus. These results indicate that
human macrophages are susceptible in vitro to productive HTLV-1 infection,
and thus might be involved in the pathogenesis of HTLV-1-related diseases.
Volume 81,
Issue 6,
pp. 1598-1606,
03/15/1993
Copyright © 1993 by The American Society of Hematology
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