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Dietary omega-3 fatty acids lower levels of platelet-derived growth factor
mRNA in human mononuclear cells
WE Kaminski, E Jendraschak, R Kiefl and C von Schacky
Medizinische Klinik, Klinikum Innenstadt, University of Munich, Germany.
Platelet-derived growth factor (PDGF) is a potent mitogen thought to
propagate atherosclerosis and other proliferative or inflammatory diseases.
Some of these diseases are ameliorated in humans by ingestion of omega-3
fatty acids. We investigated mRNA expression of both PDGF-A and PDGF-B in
quiescent peripheral blood mononuclear cells from healthy male volunteers.
For this, a highly sensitive, quantitative polymerase chain reaction
strategy (3n-PCR) was developed. In contrast to granulocytes, both PDGF-A
and PDGF-B mRNAs are expressed in mononuclear cells. This expression occurs
at a remarkably constant rate. Moreover, effects of 7 g/d of a 85% omega-3
fatty acid fish oil concentrate were investigated in a 6-week controlled,
randomized, observer-blind study in 14 human volunteers, 7 of whom served
as controls. omega-3 Fatty acids increased in mononuclear cell
phospholipids. We demonstrate for the first time that diet affects human
gene regulation. Dietary omega-3 fatty acids downregulate gene expression
of both PDGF-A (-66%), and PDGF-B (-70%). This may represent a novel
mechanism for the antifibrotic and antiatherosclerotic action of omega-3
fatty acids.
Volume 81,
Issue 7,
pp. 1871-1879,
04/01/1993
Copyright © 1993 by The American Society of Hematology
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