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Stimulation of monocyte chemotaxis by human growth hormone and its
deactivation by somatostatin
CJ Wiedermann, N Reinisch and H Braunsteiner
Department of Internal Medicine, School of Medicine, University of
Innsbruck, Austria.
Monocyte infiltration occurs early in the course of inflammation and is a
prerequisite for optimal repair of tissue damage. In this study, human
recombinant growth hormone was shown to be a potent chemoattractant for
human monocytes, inducing migration at picomolar concentrations of
recombinant human growth hormone. Chemotaxis of monocytes was measured in
vitro by a modified Boyden chamber assay using nitrocellulose micropore
filters and measuring microscopically the migration depth of the leading
front of monocytes. Somatostatin, which inhibits the release of growth
hormone, and its long-acting analogue, octreotide, also stimulated
chemotaxis of monocytes; however, the effective peptide concentration was
in the micromolar range. When tested for chemotaxis in combination or in
experiments using pretreatment with somatostatin and washing of treated
cells, somatostatin significantly antagonized the chemotactic responses of
monocytes to growth hormone. The inhibitory effect on growth hormone-
stimulated chemotaxis was dose dependent and occurred at concentrations
severalfold lower than the chemotactically active concentration of
somatostatin. Combinations of growth hormone with interferon or substance P
also deactivated the chemotactic responses. These observations suggest that
human growth hormone may have a regulatory role in monocyte chemotaxis.
Volume 82,
Issue 3,
pp. 954-960,
08/01/1993
Copyright © 1993 by The American Society of Hematology
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