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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Thein, S. L. Articles by Galvin, M. C. Search for Related Content PubMed PubMed Citation Articles by Thein, S. L. Articles by Galvin, M. C. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Beta-thalassemia unlinked to the beta-globin gene in an English family SL Thein, WG Wood, SN Wickramasinghe and MC Galvin MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford, UK. An inherited hypochromic microcytic anemia transmitted in an autosomal manner has been observed in three generations of an English family. Affected members had the hallmarks of heterozygous beta-thalassemia, ie, elevated levels of hemoglobin A2 and imbalanced globin chain synthesis. However, despite extensive sequence analysis, no mutations could be found in or around the beta-globin genes of either the propositus or two other affected members from two different generations. Linkage analysis using restriction fragment length polymorphisms in the beta-globin gene cluster clearly showed that the gene responsible for the beta-thalassemia phenotype segregates independently of the beta-gene complex. Therefore, this condition represents a novel form of the disease. Volume 82, Issue 3, pp. 961-967, 08/01/1993 Copyright © 1993 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. R. Higgs Ham-Wasserman Lecture: Gene Regulation in Hematopoiesis: New Lessons from Thalassemia Hematology, January 1, 2004; 2004(1): 1 - 13. [Abstract] [Full Text] [PDF] A. Leder, E. Wiener, M. J. Lee, S. N. Wickramasinghe, and P. Leder A normal beta -globin allele as a modifier gene ameliorating the severity of alpha -thalassemia in mice PNAS, May 25, 1999; 96(11): 6291 - 6295. [Abstract] [Full Text] [PDF] P. J. Ho, G. W. Hall, S. Watt, N. C. West, J. W. Wimperis, W. G. Wood, and S. L. Thein Unusually Severe Heterozygous beta -Thalassemia: Evidence for an Interacting Gene Affecting Globin Translation Blood, November 1, 1998; 92(9): 3428 - 3435. [Abstract] [Full Text] [PDF] D.C. Rees, L.Y. Luo, and S.L. Thein Nontransfusional Iron Overload in Thalassemia: Association With Hereditary Hemochromatosis Blood, October 15, 1997; 90(8): 3234 - 3035. [Full Text] [PDF]

	Copyright © 1993 by American Society of Hematology         Online ISSN: 1528-0020