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6q deletions define distinct clinico-pathologic subsets of non- Hodgkin's
lymphoma
K Offit, NZ Parsa, G Gaidano, DA Filippa, D Louie, D Pan, SC Jhanwar, R Dalla- Favera and RS Chaganti
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York,
NY 10021.
Commonly observed in lymphoid neoplasms, deletions of 6q have been
correlated with histologic and clinical subsets of non-Hodgkin's lymphoma
(NHL). Our recent analysis of loss of heterozygosity of 6q loci in NHL
showed two regions of minimal molecular deletion (RMD), an RMD1 at 6q25-27
and an RMD2 at 6q21-23. To establish correlations between these RMDs and
regions of minimal cytogenetic deletions (RCDs) on 6q, and to define
associations between RCDs and clinico-pathologic features, we have analyzed
chromosome 6 abnormalities in 459 consecutively ascertained, karyotypically
abnormal cases of NHL. Among these, 126 (27.5%) cases had structural
abnormalities of chromosome 6, of which 94 were deletions. Analysis of
these deletions identified three RCDs. An RCD1 encompassing 6q25-27 was
seen in 45 intermediate- grade NHL. An RCD2 at 6q21 was observed in 11
high-grade NHL, 9 of which were of the immunoblastic subtype. An RCD3 at
6q23 was noted in 18 low-grade NHL lacking a t(14;18) translocation. Of
these 18 cases, 12 were small lymphocytic NHL and, in 2 of these, del(6q)
was the sole karyotypic abnormality. In 20 cases of low-grade NHL with
t(14;18), the deletions spanned both RCD1 and RCD3. These data suggested
the presence of at least 3 tumor suppressor genes on 6q within RCD1, RCD2,
and RCD3; they also showed associations between RCDs in 6q and subsets of
NHL, including a specific association between a group of
well-differentiated lymphoid neoplasms and RCD3. The apparent heterogeneity
of breakpoints when all NHLs are considered together explains the inability
of previous studies to reliably establish correlations between recurring 6q
deletions and histologic and clinical features of NHL.
Volume 82,
Issue 7,
pp. 2157-2162,
10/01/1993
Copyright © 1993 by The American Society of Hematology
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|
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|
|
|
|
|
|
|
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3371 - 3377.
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|
|
|
|
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