|
|
 Previous Article | Table of Contents | Next Article 
Clonal, nonconstitutional rearrangements of the MLL gene in infant twins
with acute lymphoblastic leukemia: in utero chromosome rearrangement of
11q23
HJ Gill Super, PG Rothberg, H Kobayashi, AI Freeman, MO Diaz and JD Rowley
Department of Medicine, University of Chicago, IL 60637.
Rearrangements of chromosome band 11q23 are common in infant leukemias,
comprising more than 70% of the observed chromosome abnormalities in
children less than 1 year of age. The MLL gene, which is located at the
11q23 breakpoint in infant, childhood, and adult acute leukemias, has been
cloned and has homology to the Drosophila trithorax gene. The breakpoints
in MLL are restricted to an 8.3-kilobase pair (kb) region of the gene that
is involved in translocations with as many as 29 other chromosomal regions
in a number of phenotypically distinct acute leukemias. We have detected an
identical, clonal, nonconstitutional rearrangement of the MLL gene in
peripheral blood cells from a pair of female infants twins with acute
lymphoblastic leukemia (ALL) and a t(11;19)(q23;p13.3). The detection of
nonidentical IGH rearrangements suggests that the MLL rearrangement took
place in a B-cell precursor or hematopoietic stem cell in one twin which
was transferred in utero to the other fetus resulting in ALL with an
identical aneuploid karyotype in both infants. We speculate that the other
MLL-related infant leukemias may also develop in utero, and that the
rearrangements may occur consistently in stem cells or early precursor
cells, accounting for the frequency of mixed-lineage leukemia in infants.
Volume 83,
Issue 3,
pp. 641-644,
02/01/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. M. Murray, J. P. O'Neill, T. Messier, J. Rivers, V. E. Walker, B. McGonagle, L. Trombley, L. G. Cowell, G. Kelsoe, F. McBlane, et al.
V(D)J Recombinase-Mediated Processing of Coding Junctions at Cryptic Recombination Signal Sequences in Peripheral T Cells during Human Development
J. Immunol.,
October 15, 2006;
177(8):
5393 - 5404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. Greaves, A. T. Maia, J. L. Wiemels, and A. M. Ford
Leukemia in twins: lessons in natural history
Blood,
October 1, 2003;
102(7):
2321 - 2333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Robien and C. M. Ulrich
5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Leukemia Risk: A HuGE Minireview
Am. J. Epidemiol.,
April 1, 2003;
157(7):
571 - 582.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Wiemels, Z. Xiao, P. A. Buffler, A. T. Maia, X. Ma, B. M. Dicks, M. T. Smith, L. Zhang, J. Feusner, J. Wiencke, et al.
In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
Blood,
May 15, 2002;
99(10):
3801 - 3805.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. Taub, M. A. Konrad, Y. Ge, J. M. Naber, J. S. Scott, L. H. Matherly, and Y. Ravindranath
High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia
Blood,
April 15, 2002;
99(8):
2992 - 2996.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. T. Maia, A. M. Ford, G. R. Jalali, C. J. Harrison, G. M. Taylor, O. B. Eden, and M. F. Greaves
Molecular tracking of leukemogenesis in a triplet pregnancy
Blood,
July 15, 2001;
98(2):
478 - 482.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yoshioka, J. P. O’Neill, P. M. Vacek, and B. A. Finette
Gestational Age and Gender-specific In Utero V(D)J Recombinase-mediated Deletions
Cancer Res.,
April 1, 2001;
61(8):
3432 - 3438.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Fasching, S. Panzer, O. A. Haas, R. Marschalek, H. Gadner, and E. R. Panzer-Grumayer
Presence of clone-specific antigen receptor gene rearrangements at birth indicates an in utero origin of diverse types of early childhood acute lymphoblastic leukemia
Blood,
April 15, 2000;
95(8):
2722 - 2724.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Dordelmann, A. Reiter, A. Borkhardt, W.-D. Ludwig, N. Gotz, S. Viehmann, H. Gadner, H. Riehm, and M. Schrappe
Prednisone Response Is the Strongest Predictor of Treatment Outcome in Infant Acute Lymphoblastic Leukemia
Blood,
August 15, 1999;
94(4):
1209 - 1217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Wiemels, A. M. Ford, E. R. Van Wering, A. Postma, and M. Greaves
Protracted and Variable Latency of Acute Lymphoblastic Leukemia After TEL-AML1 Gene Fusion In Utero
Blood,
August 1, 1999;
94(3):
1057 - 1062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Felix and B. J. Lange
Leukemia in Infants
Oncologist,
June 1, 1999;
4(3):
225 - 240.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Yoshioka, P. M. Vacek, T. Poseno, R. Silver, and B. A. Finette
Gender-specific frequency of background somatic mutations at the hypoxanthine phosphoribosyltransferase locus in cord blood T lymphocytes from preterm newborns
PNAS,
January 19, 1999;
96(2):
586 - 591.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Sun, N. Heerema, L. Crotty, X. Wu, C. Navara, A. Vassilev, M. Sensel, G. H. Reaman, and F. M. Uckun
Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia
PNAS,
January 19, 1999;
96(2):
680 - 685.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Megonigal, E. F. Rappaport, D. H. Jones, T. M. Williams, B. D. Lovett, K. M. Kelly, P. H. Lerou, T. Moulton, M. L. Budarf, and C. A. Felix
t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes
PNAS,
May 26, 1998;
95(11):
6413 - 6418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Ford, C. A. Bennett, C. M. Price, M. C. A. Bruin, E. R. Van Wering, and M. Greaves
Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia
PNAS,
April 14, 1998;
95(8):
4584 - 4588.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. B. Gale, A. M. Ford, R. Repp, A. Borkhardt, C. Keller, O. B. Eden, and M. F. Greaves
Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots
PNAS,
December 9, 1997;
94(25):
13950 - 13954.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Butler, R. Slany, X. Cui, M. L. Cleary, and D. Y. Mason
The HRX Proto-oncogene Product Is Widely Expressed in Human Tissues and Localizes to Nuclear Structures
Blood,
May 1, 1997;
89(9):
3361 - 3370.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Ford, M. S. Pombo-de-Oliveira, K. P. McCarthy, J. M. MacLean, K. C. Carrico, R. F. Vincent, and M. Greaves
Monoclonal Origin of Concordant T-Cell Malignancy in Identical Twins
Blood,
January 1, 1997;
89(1):
281 - 285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Strick, P. L. Strissel, S. Borgers, S. L. Smith, and J. D. Rowley
From the Cover: Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
PNAS,
April 25, 2000;
97(9):
4790 - 4795.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
