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Expression of the c-kit receptor in human lymphomas is restricted to
Hodgkin's disease and CD30+ anaplastic large cell lymphomas
A Pinto, A Gloghini, V Gattei, D Aldinucci, V Zagonel and A Carbone
Leukemia Unit, Centro di Riferimento Oncologico, INRCCS, Aviano, Italy.
The product of the proto-oncogene c-kit is a transmembrane receptor protein
that plays an important role in the regulation of normal and neoplastic
hematopoiesis via the interaction with its specific ligand termed stem cell
factor. To examine whether c-kit product is possibly involved in the
pathogenesis of human lymphomas, we analyzed the expression of the c-kit
protein in neoplastic cells from a variety of lymphoid tumors by
immunostaining of lymph node frozen sections with the 17F11 antibody,
detecting an extracellular epitope of the c-kit receptor, and of c-kit RNA
by Northern blot hybridization. Of 24 nonHodgkin's lymphomas (NHL) of B-
and T-cell phenotype, none expressed immunodetectable c-kit protein that
was also not evidenced in lymphoid cells of reactive lymph nodes and normal
tonsils. In contrast, c-kit protein was expressed by Reed-Sternberg cells
and their mononuclear variants from 11 of 21 Hodgkin's disease (HD) cases,
and in tumor cells from 11 of 16 cases of CD30+ anaplastic large cell
lymphoma (ALCL). c- kit specific mRNA was also detected in lymph node
tissues from HD and ALCL cases but not in neoplastic tissues from NHL other
than ALCL. In addition, c-kit/CD30+ tumor cells were evidenced by flow
cytometry in a patient displaying massive bone marrow involvement by ALCL.
With the exclusion of lymphocyte predominance cases of HD that resulted
c-kit expression and the other histologic subtypes of HD or the immunologic
phenotype of tumor cells (B, T, nonB-nonT) in both HD and ALCL. The highly
restricted expression of the c-kit product among human lymphomas to HD and
ALCL provides a further biologic link between these two closely related
lymphoma entities.
Volume 83,
Issue 3,
pp. 785-792,
02/01/1994
Copyright © 1994 by The American Society of Hematology
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