|
 Previous Article | Table of Contents | Next Article 
Production of hematopoietic stem cell-chemotactic factor by bone marrow
stromal cells
Cherry, R Yasumizu, J Toki, H Asou, T Nishino, Y Komatsu and S Ikehara
Department of Pathology, Kansai Medical University, Osaka, Japan.
Chemotactic factors produced by stromal cells in the bone marrow are
characterized. Two kinds of factors produced by stromal cell lines are
identified using blind-well Boyden's Chambers; one is a neutrophil-
chemotactic factor and the other a hematopoietic stem cell (HSC)-
chemotactic factor. The latter attracts blastic cells in a low-density
fraction, which are Thy1lo, wheat germ agglutinin (WGA)hi, H-2Khi, Ly-1- ,
Ly-2-, L3T4-, Ly5-, and slg-. The molecular weight of this HSC- chemotactic
factor is estimated to be more than 200 kD. Putative cytokines and growth
factors, such as granulocyte colony-stimulating factor (CSF), macrophage
CSF, granulocyte-macrophage CSF, stem cell factor (SCF), interleukin
(IL)-6, and IL-3, do not possess HSC- chemotactic activity. These findings
strongly suggest that bone marrow stromal cells produce a new factor that
attracts HSCs.
Volume 83,
Issue 4,
pp. 964-971,
02/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Campagnoli, I. A. G. Roberts, S. Kumar, P. R. Bennett, I. Bellantuono, and N. M. Fisk
Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
Blood,
October 15, 2001;
98(8):
2396 - 2402.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.-X. Fan, H. Hisha, T.-N. Jin, C.-Z. Yu, Z.-X. Lian, S.-B. Guo, Y.-Z. Cui, B. Feng, G.-X. Yang, Q. Li, et al.
Successful Allogeneic Bone Marrow Transplantation (BMT) by Injection of Bone Marrow Cells via Portal Vein: Stromal Cells as BMT-Facilitating Cells
Stem Cells,
February 1, 2001;
19(2):
144 - 150.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Kinoshita, T. Sekiguchi, M.-j. Xu, Y. Ito, A. Kamiya, K.-i. Tsuji, T. Nakahata, and A. Miyajima
Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis
PNAS,
June 22, 1999;
96(13):
7265 - 7270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. H. Kim and H. E. Broxmeyer
In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell-Derived Factor-1, Steel Factor, and the Bone Marrow Environment
Blood,
January 1, 1998;
91(1):
100 - 110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Guerriero, L. Worford, H. K. Holland, G.-R. Guo, K. Sheehan, and E. K. Waller
Thrombopoietin Is Synthesized by Bone Marrow Stromal Cells
Blood,
November 1, 1997;
90(9):
3444 - 3455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kawamura, H. Hisha, Y. Li, S. Fukuhara, and S. Ikehara
Distinct Qualitative Differences between Normal and Abnormal Hemopoietic Stem Cells In Vivo and In Vitro
Stem Cells,
January 1, 1997;
15(1):
56 - 62.
[Abstract]
[Full Text]
|
|
|
|
|
