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Recombinant human interleukin-11 stimulates multilineage hematopoietic
recovery in mice after a myelosuppressive regimen of sublethal irradiation
and carboplatin
JP Leonard, CM Quinto, MK Kozitza, TY Neben and SJ Goldman
Genetics Institute, Cambridge, MA 02140.
Interleukin-11 (IL-11) is a novel multifunctional hematopoietic cytokine
capable of stimulating cells of the myeloid, lymphoid, erythroid, and
megakaryocytic lineages in vitro. We have tested the pleiotropic properties
of this cytokine on the hematopoietic recovery of mice after a combined
regimen of sublethal irradiation and carboplatin administration. This
regimen results in severe myelosuppression, characterized by a prolonged
period of thrombocytopenia and severe anemia. Administration of recombinant
human IL-11 (rhIL-11; 250 micrograms/kg/d) had multilineage effects on bone
marrow and spleen hematopoietic activity, increasing the number of
megakaryocyte, erythroid, granulocyte, and macrophage progenitors compared
with the vehicle-treated controls. This was reflected in the peripheral
circulation by a reduction of both the platelet and hematocrit nadirs and a
significantly reduced period of thrombocytopenia and anemia in the
rhIL-11-treated mice. The results from this study support the broad
spectrum of biologic activities that have been attributed to rhIL-11 in
vitro and suggest that this cytokine may be an effective agent in the
treatment of myelosuppression associated with cancer chemotherapy and bone
marrow transplantation.
Volume 83,
Issue 6,
pp. 1499-1506,
03/15/1994
Copyright © 1994 by The American Society of Hematology
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