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Differential effect of growth hormone and insulin-like growth factor-I,
insulin-like growth factor-II, and insulin on Ig production and growth in
human plasma cells
H Kimata and A Yoshida
Department of Pediatrics, Kyoto University Hospital, Japan.
The effect of human growth hormone (GH) and insulin-like growth factor- I
(IGF-I), IGF-II, and insulin on human plasma cell responses was studied. GH
enhanced Ig production and thymidine uptake in the human plasma cell lines,
IM-9 and AF-10. IGF-I, but not IGF-II or insulin, also enhanced Ig
production and proliferation in them. However, enhancement by GH was not
mediated by IGF-I, because enhancement was blocked by anti-GH antibody
(Ab), but not by Ab to IGF-I or IGF-I receptor. Conversely, the enhancement
by IGF-I was blocked by either Ab to IGF-I or IGF-I receptor, but not by
anti-GH Ab. GH and IGF-I also enhanced production of IgG1, IgG2, IgG3,
IgG4, IgA1, IgA2, and IgM and thymidine uptake in PCA-1+ plasma cells
generated in vitro. Again, enhancement by GH was specifically blocked by
anti-GH Ab, whereas enhancement by IGF-I was specifically blocked by either
Ab to IGF-I or IGF-I receptor. These results indicate that GH and IGF-I may
play important roles in plasma cell responses.
Volume 83,
Issue 6,
pp. 1569-1574,
03/15/1994
Copyright © 1994 by The American Society of Hematology
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