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Murine yolk sac endoderm- and mesoderm-derived cell lines support in vitro
growth and differentiation of hematopoietic cells
MC Yoder, VE Papaioannou, PP Breitfeld and DA Williams
Herman B Wells Center for Pediatric Research, Department of Pediatrics,
Indiana University School of Medicine, Indianapolis.
The mechanisms involved in the induction of yolk sac mesoderm into blood
islands and the role of visceral endoderm and mesoderm cells in regulating
the restricted differentiation and proliferation of hematopoietic cells in
the yolk sac remain largely unexplored. To better define the role of murine
yolk sac microenvironment cells in supporting hematopoiesis, we established
cell lines from day-9.5 gestation murine yolk sac visceral endoderm and
mesoderm layers using a recombinant retrovirus vector containing Simian
virus 40 large T- antigen cDNA. Obtained immortalized cell lines expressed
morphologic and biosynthetic features characteristic of endoderm and
mesoderm cells from freshly isolated yolk sacs. Similar to the
differentiation of blood island hematopoietic cells in situ,
differentiation of hematopoietic progenitor cells in vitro into neutrophils
was restricted and macrophage production increased when bone marrow (BM)
progenitor cells were cultured in direct contact with immortalized yolk sac
cell lines as compared with culture on adult BM stromal cell lines. Yolk
sac- derived cell lines also significantly stimulated the proliferation of
hematopoietic progenitor cells compared with the adult BM stromal cell
lines. Thus, yolk sac endoderm- and mesoderm-derived cells, expressing many
features of normal yolk sac cells, alter the growth and differentiation of
hematopoietic progenitor cells. These cells will prove useful in examining
the cellular interactions between yolk sac endoderm and mesoderm involved
in early hematopoietic stem cell proliferation and differentiation.
Volume 83,
Issue 9,
pp. 2436-2443,
05/01/1994
Copyright © 1994 by The American Society of Hematology
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