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Effect of retinoic acid on HL-60 cells infected with human immunodeficiency virus type 1

M Semmel, A Macho, D Coulaud, A Alileche, S Plaisance, J Aguilar and C Jasmin

Unite 268 INSERM, Villejui, France.

HL-60 cells infected with human immunodeficiency virus type 1 (HIV 1) can be induced to differentiate along the granulocyte pathway by retinoic acid. In these cells, HIV mRNA synthesis is stimulated, but synthesis of viral proteins and virus replication are blocked and HIV- infected cells die after becoming apoptotic and/or vacuolized.

Volume 84, Issue 8, pp. 2480-2488, 10/15/1994
Copyright © 1994 by The American Society of Hematology


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  Copyright © 1994 by American Society of Hematology         Online ISSN: 1528-0020