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Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro J Maciejewski, C Selleri, S Anderson and NS Young Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Activation of Fas antigen, a cell surface receptor molecule, by its ligand results in transduction of a signal for cell death. The Fas system has been implicated in target cell recognition, clonal development of immune effector cells, and termination of the cellular immune response. Fas antigen expression on lymphocytes is regulated by interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha), cytokines that also have inhibitory effects on hematopoiesis. We investigated Fas antigen expression on human marrow cells and the effects of Fas activation on hematopoiesis in vitro. Freshly isolated immature hematopoietic cells, as defined by the CD34 marker, did not express Fas antigen at levels detectable by fluorescent staining. CD34+ cells, which include progenitors and stem cells, showed low levels of Fas expression in culture, even in the presence of growth factors. Stimulation by TNF alpha and IFN gamma markedly increased Fas antigen expression on CD34+ cells. Anti-Fas antibody, which mimics the action of the putative ligand, enhanced IFN gamma- and TNF alpha-mediated suppression of colony formation by bone marrow (BM) in a dose-dependent manner. This effect did not require the presence of accessory cells. Colony formation from mature (CD34+ CD38+) and immature (CD34+ CD38-) progenitor cells and long-term culture initiating cells were susceptible to the inhibitory action of anti-Fas antibody in the presence of IFN gamma and TNF alpha. Apoptosis assays performed on total BM cells and CD34+ cells showed that anti-Fas antibody induced programmed cell death of CD34+ BM cells.(ABSTRACT TRUNCATED AT 250 WORDS) Volume 85, Issue 11, pp. 3183-3190, 06/01/1995 Copyright © 1995 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. O. Iversen, K. B. Andersson, A. V. Finsen, I. Sjaastad, T. G. von Lueder, O. M. Sejersted, H. Attramadal, and G. Christensen Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2010; 298(3): R808 - R814. [Abstract] [Full Text] [PDF] Y. Tang, M. J. Desierto, J. Chen, and N. S. Young The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure Blood, January 21, 2010; 115(3): 541 - 548. [Abstract] [Full Text] [PDF] C. Dufour, E. Ferretti, F. Bagnasco, O. 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