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Regulation of cell adhesion molecule expression and function associated
with neutrophil apoptosis
I Dransfield, SC Stocks and C Haslett
Department of Medicine, University of Edinburgh, UK.
We have investigated the adhesive capacity of neutrophils after spontaneous
apoptosis, which occurs during in vitro culture. Apoptotic neutrophils show
reduced adhesion to E selectin and the CD18 integrin ligand fibrinogen.
Neutrophil apoptosis is associated with changes in the levels of surface
expression of key receptors that mediate neutrophil adhesion events.
Notably, apoptotic neutrophils show reduced expression of
L-selectin/selectin ligand. In contrast, CD11b/CD18 and CD11c/CD18
integrins are expressed at increased levels. The reduced capacity for
adhesion of apoptotic neutrophils may be achieved by very different
mechanisms. Regulation of the levels of surface expression of
receptors/ligand may control selectin-mediated adhesion, possibly as a
result of protease/sialidase activity. In contrast, modulation of
integrin-mediated adhesion may involve functional uncoupling of receptors
present on the surface of the apoptotic cell without alteration in levels
of surface expression. The altered adhesive potential of the apoptotic
neutrophil may serve to limit release of its histotoxic contents and reduce
inappropriate tissue injury.
Volume 85,
Issue 11,
pp. 3264-3273,
06/01/1995
Copyright © 1995 by The American Society of Hematology
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