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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Romana, S. Articles by Bernard, O. Search for Related Content PubMed PubMed Citation Articles by Romana, S. Articles by Bernard, O. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion SP Romana, M Mauchauffe, M Le Coniat, I Chumakov, D Le Paslier, R Berger and OA Bernard U 301 de l'Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, France. Analysis of a growing number of chromosomal translocations in human tumors have shown that they frequently result in gene fusions encoding chimeric proteins. We have characterized the recurrent t(12;21)(p12;q22) translocation present in human B-lineage acute leukemias. This translocation fused two genes, tel and AML1, that have previously been described in chromosomal translocations specific for myeloid malignancies. These two genes therefore belong to an increasing number of human genes that are involved in a variety of hematopoietic malignant disorders and can be rearranged with numerous partners. Interestingly, in these acute leukemias, deletion of the other tel allele from the normal chromosome 12 was associated with the tel rearrangement, whereas both tel alleles were present in the chronic leukemias bearing a t(5;12) that we have tested. Volume 85, Issue 12, pp. 3662-3670, 06/15/1995 Copyright © 1995 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. DE BRAEKELEER, C. FEREC, and M. DE BRAEKELEER RUNX1 Translocations in Malignant Hemopathies Anticancer Res, April 1, 2009; 29(4): 1031 - 1037. [Abstract] [Full Text] [PDF] L. Roudaia, M. D. Cheney, E. Manuylova, W. Chen, M. Morrow, S. Park, C.-T. Lee, P. Kaur, O. Williams, J. H. Bushweller, et al. CBF{beta} is critical for AML1-ETO and TEL-AML1 activity Blood, March 26, 2009; 113(13): 3070 - 3079. [Abstract] [Full Text] [PDF] J. E. Rubnitz, D. Wichlan, M. Devidas, J. Shuster, S. B. Linda, J. Kurtzberg, B. Bell, S. P. Hunger, A. Chauvenet, C.-H. Pui, et al. Prospective Analysis of TEL Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia: A Children's Oncology Group Study J. Clin. Oncol., May 1, 2008; 26(13): 2186 - 2191. 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