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High expression of latent membrane protein 1 of Epstein-Barr virus and
BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary
brain lymphomas
S Camilleri-Broet, F Davi, J Feuillard, C Bourgeois, D Seilhean, JJ Hauw and M Raphael
Departement de Neuropathologie INSERM U360, CHU Pitie-Salpetriere, Paris,
France.
Nearly all primary brain lymphomas in acquired immunodeficiency syndrome
(AIDS) patients are associated withEpstein-Barr virus (EBV). The role of
EBV in lymphomagenesis is not totally elucidated. One possible mechanism is
the overexpression of the BCL-2 oncoprotein, because the latent membrane
protein 1 (LMP1) has been reported to transactivate the bcl-2 gene in
vitro. To study the interrelationship beetween LMP1 and BCL-2 in vivo, we
have analyzed and compared their expression in 11 AIDS-related primary
brain lymphomas and 57 AIDS- related systemic lymphomas by immunoperoxidase
technique on frozen sections. In AIDS-related primary brain lymphoma, LMP1
and BCL-2 were expressed in all cases but 1. All positive cases exhibited
morphologic immunoblastic features. In contrast, the only negative case was
histologically close to Burkitt's lymphoma. In systemic lymphomas, LMP1 was
expressed in 21 cases, whereas BCL-2 was positive in only 3 cases, all of
which were extranodal. These results indicate that, in addition to the
histologic type, the role of EBV genes and BCL-2 expression in lymphomatous
cells differ as a function of their localization. In AIDS- related primary
brain lymphomas, this correlation between LMP1 and BCL- 2 overexpression
may have a major implication in lymphomagenesis.
Volume 86,
Issue 2,
pp. 432-435,
07/15/1995
Copyright © 1995 by The American Society of Hematology
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