|
|
 Previous Article | Table of Contents | Next Article 
Adhesion receptors on bone marrow stromal cells: in vivo expression of
vascular cell adhesion molecule-1 by reticular cells and sinusoidal
endothelium in normal and gamma-irradiated mice
K Jacobsen, J Kravitz, PW Kincade and DG Osmond
Department of Anatomy and Cell Biology, McGill University, Montreal,
Canada.
Cell adhesion molecules (CAMs) play a key role in interactions between
stromal and hematopoietic cells in bone marrow (BM) and in cell traffic
through vascular endothelium. To examine the identity of CAMs involved in
these processes in mouse BM, we have investigated the in vivo expression of
vascular cell adhesion molecule-1 (VCAM-1) and its counter-receptor, very
late antigen-4 (VLA-4). Radioiodinated monoclonal antibodies (MoAbs)
detecting VLA-4 and VCAM-1 were injected intravenously. Antibody binding
was detected in BM by light and electron microscope radioautography. VCAM-1
labeling was restricted to stromal reticular cells and endothelial cells
lining BM sinusoids. VCAM- 1+ reticular cells formed patchy concentrations,
especially in subosteal regions, associated with lymphoid, granulocytic,
and erythroid cells. After gamma-irradiation to deplete hematopoietic
cells, reticular cells and endothelial cells all showed VCAM-1 labeling in
apparently increased intensity. VLA-4 labeling was shown by
undifferentiated blast cells and lymphohematopoietic cells both in BM cell
suspensions and in vivo, especially at reticular cell contact points. The
results demonstrate that VCAM-1 is expressed in vivo by certain BM
reticular cells, suggesting that the molecule mediates adhesion to multiple
lineages of lymphohematopoietic cells. The finding that VCAM-1 is also
expressed constitutively by BM sinusoidal endothelium, unlike its inductive
expression by endothelia elsewhere, suggests that VCAM-1 and VLA-4 may be
involved in regulating the normal cell traffic between BM and the blood
stream.
Volume 87,
Issue 1,
pp. 73-82,
01/01/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. M. Boehmler, A. Drost, L. Jaggy, G. Seitz, T. Wiesner, C. Denzlinger, L. Kanz, and R. Mohle
The CysLT1 Ligand Leukotriene D4 Supports {alpha}4{beta}1- and {alpha}5{beta}1-Mediated Adhesion and Proliferation of CD34+ Hematopoietic Progenitor Cells
J. Immunol.,
June 1, 2009;
182(11):
6789 - 6798.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Petty, C. C. Lenox, D. J. Weiss, M. E. Poynter, and B. T. Suratt
Crosstalk between CXCR4/Stromal Derived Factor-1 and VLA-4/VCAM-1 Pathways Regulates Neutrophil Retention in the Bone Marrow
J. Immunol.,
January 1, 2009;
182(1):
604 - 612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kumar and S. Ponnazhagan
Bone homing of mesenchymal stem cells by ectopic {alpha}4 integrin expression
FASEB J,
December 1, 2007;
21(14):
3917 - 3927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-Y. Lin, D. Lu, C.-F. Hung, S. Peng, L. Huang, C. Jie, F. Murillo, J. Rowley, Y.-C. Tsai, L. He, et al.
Ectopic Expression of Vascular Cell Adhesion Molecule-1 as a New Mechanism for Tumor Immune Evasion
Cancer Res.,
February 15, 2007;
67(4):
1832 - 1841.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pihlgren, M. Friedli, C. Tougne, A.-F. Rochat, P.-H. Lambert, and C.-A. Siegrist
Reduced Ability of Neonatal and Early-Life Bone Marrow Stromal Cells to Support Plasmablast Survival
J. Immunol.,
January 1, 2006;
176(1):
165 - 172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Rosenthal-Allieri, M. Ticchioni, J. P. Breittmayer, Y. Shimizu, and A. Bernard
Influence of {beta}1 Integrin Intracytoplasmic Domains in the Regulation of VLA-4-Mediated Adhesion of Human T Cells to VCAM-1 under Flow Conditions
J. Immunol.,
July 15, 2005;
175(2):
1214 - 1223.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N Cordes and V Meineke
Modification of the cellular radiation survival and proliferation response by cell-matrix interactions: implications for integrin targeting in therapeutic approaches for radiation accident patients
Br. J. Radiol.,
January 1, 2005;
Supplement_27(1):
152 - 156.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sakaguchi, I. Sekiya, K. Yagishita, S. Ichinose, K. Shinomiya, and T. Muneta
Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates
Blood,
November 1, 2004;
104(9):
2728 - 2735.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Mori, N. Shimizu, M. Dallas, M. Niewolna, B. Story, P. J. Williams, G. R. Mundy, and T. Yoneda
Anti-{alpha}4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis
Blood,
October 1, 2004;
104(7):
2149 - 2154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. G. Winkler, K. R. Snapp, P. J. Simmons, and J.-P. Levesque
Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1
Blood,
March 1, 2004;
103(5):
1685 - 1692.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sengupta, S. Caballero, R. N. Mames, J. M. Butler, E. W. Scott, and M. B. Grant
The Role of Adult Bone Marrow-Derived Stem Cells in Choroidal Neovascularization
Invest. Ophthalmol. Vis. Sci.,
November 1, 2003;
44(11):
4908 - 4913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Scortegagna, M. A. Morris, Y. Oktay, M. Bennett, and J. A. Garcia
The HIF family member EPAS1/HIF-2{alpha} is required for normal hematopoiesis in mice
Blood,
September 1, 2003;
102(5):
1634 - 1640.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Erratum for vol. 100, p. 3545
Blood,
January 15, 2003;
101(2):
390 - 390.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. A. M. Wols, G. H. Underhill, G. S. Kansas, and P. L. Witte
The Role of Bone Marrow-Derived Stromal Cells in the Maintenance of Plasma Cell Longevity
J. Immunol.,
October 15, 2002;
169(8):
4213 - 4221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. B. Mazo, E. J. Quackenbush, J. B. Lowe, and U. H. von Andrian
Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow
Blood,
May 13, 2002;
99(11):
4182 - 4191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. H. Underhill, H. A. Minges-Wols, J. L. Fornek, P. L. Witte, and G. S. Kansas
IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules
Blood,
April 15, 2002;
99(8):
2905 - 2912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Jetmore, P. A. Plett, X. Tong, F. M. Wolber, R. Breese, R. Abonour, C. M. Orschell-Traycoff, and E. F. Srour
Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34+ cells transplanted into conditioned NOD/SCID recipients
Blood,
March 1, 2002;
99(5):
1585 - 1593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Papayannopoulou, G. V. Priestley, B. Nakamoto, V. Zafiropoulos, and L. M. Scott
Molecular pathways in bone marrow homing: dominant role of {alpha}4{beta}1 over {beta}2-integrins and selectins
Blood,
October 15, 2001;
98(8):
2403 - 2411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Bautz, C. Denzlinger, L. Kanz, and R. Mohle
Chemotaxis and transendothelial migration of CD34+ hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1
Blood,
June 1, 2001;
97(11):
3433 - 3440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Papayannopoulou, G. V. Priestley, B. Nakamoto, V. Zafiropoulos, L. M. Scott, and J. M. Harlan
Synergistic mobilization of hemopoietic progenitor cells using concurrent {beta}1 and {beta}2 integrin blockade or {beta}2-deficient mice
Blood,
March 1, 2001;
97(5):
1282 - 1288.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. S. Frenette and L. Weiss
Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms
Blood,
October 1, 2000;
96(7):
2460 - 2468.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Naiyer, D.-Y. Jo, J. Ahn, R. Mohle, M. Peichev, G. Lam, R. L. Silverstein, M. A.S. Moore, and S. Rafii
Stromal Derived Factor-1-Induced Chemokinesis of Cord Blood CD34+ Cells (Long-Term Culture-Initiating Cells) Through Endothelial Cells Is Mediated by E-Selectin
Blood,
December 15, 1999;
94(12):
4011 - 4019.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Zanjani, A. W. Flake, G. Almeida-Porada, N. Tran, and T. Papayannopoulou
Homing of Human Cells in the Fetal Sheep Model: Modulation by Antibodies Activating or Inhibiting Very Late Activation Antigen-4-Dependent Function
Blood,
October 1, 1999;
94(7):
2515 - 2522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Berlin-Rufenach, F. Otto, M. Mathies, J. Westermann, M. J. Owen, A. Hamann, and N. Hogg
Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1-deficient Mice
J. Exp. Med.,
May 3, 1999;
189(9):
1467 - 1478.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Cortes, F. Deschaseaux, N. Uchida, M.-C. Labastie, A. M. Friera, D. He, P. Charbord, and B. Peault
HCA, an Immunoglobulin-Like Adhesion Molecule Present on the Earliest Human Hematopoietic Precursor Cells, Is Also Expressed by Stromal Cells in Blood-Forming Tissues
Blood,
February 1, 1999;
93(3):
826 - 837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Imai, M. Kobayashi, J. Wang, Y. Ohiro, J.-i. Hamada, Y. Cho, M. Imamura, M. Musashi, T. Kondo, M. Hosokawa, et al.
Selective Transendothelial Migration of Hematopoietic Progenitor Cells: A Role in Homing of Progenitor Cells
Blood,
January 1, 1999;
93(1):
149 - 156.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. S. Frenette, S. Subbarao, I. B. Mazo, U. H. von Andrian, and D. D. Wagner
Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow
PNAS,
November 24, 1998;
95(24):
14423 - 14428.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. B. Mazo, J.-C. Gutierrez-Ramos, P. S. Frenette, R. O. Hynes, D. D. Wagner, and U. H. von Andrian
Hematopoietic Progenitor Cell Rolling in Bone Marrow Microvessels: Parallel Contributions by Endothelial Selectins and Vascular Cell Adhesion Molecule 1
J. Exp. Med.,
August 3, 1998;
188(3):
465 - 474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Vermeulen, F. Le Pesteur, M.-C. Gagnerault, J.-Y. Mary, F. Sainteny, and F. Lepault
Role of Adhesion Molecules in the Homing and Mobilization of Murine Hematopoietic Stem and Progenitor Cells
Blood,
August 1, 1998;
92(3):
894 - 900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F.M. Pruijt, Y. van Kooyk, C. G. Figdor, I. J.D. Lindley, R. Willemze, and W. E. Fibbe
Anti-LFA-1 Blocking Antibodies Prevent Mobilization of Hematopoietic Progenitor Cells Induced by Interleukin-8
Blood,
June 1, 1998;
91(11):
4099 - 4105.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.-S. Strobel, D. Mobest, S. von Kleist, M. Dangel, S. Ries, R. Mertelsmann, and R. Henschler
Adhesion and Migration Are Differentially Regulated in Hematopoietic Progenitor Cells by Cytokines and Extracellular Matrix
Blood,
November 1, 1997;
90(9):
3524 - 3532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Garlanda and E. Dejana
Heterogeneity of Endothelial Cells : Specific Markers
Arterioscler Thromb Vasc Biol,
July 1, 1997;
17(7):
1193 - 1202.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L.B. To, D.N. Haylock, P.J. Simmons, and C.A. Juttner
The Biology and Clinical Uses of Blood Stem Cells
Blood,
April 1, 1997;
89(7):
2233 - 2258.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Styles, B. Lubin, E. Vichinsky, S. Lawrence, M. Hua, S. Test, and F. Kuypers
Decrease of Very Late Activation Antigen-4 and CD36 on Reticulocytes in Sickle Cell Patients Treated With Hydroxyurea
Blood,
April 1, 1997;
89(7):
2554 - 2559.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Mohle, M. A.S. Moore, R. L. Nachman, and S. Rafii
Transendothelial Migration of CD34+ and Mature Hematopoietic Cells: An In Vitro Study Using a Human Bone Marrow Endothelial Cell Line
Blood,
January 1, 1997;
89(1):
72 - 80.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Simpson, J. Reiland, S. R. Burger, L. T. Furcht, A. P. Spicer, T. R. Oegema Jr., and J. B. McCarthy
Hyaluronan Synthase Elevation in Metastatic Prostate Carcinoma Cells Correlates with Hyaluronan Surface Retention, a Prerequisite for Rapid Adhesion to Bone Marrow Endothelial Cells
J. Biol. Chem.,
May 18, 2001;
276(21):
17949 - 17957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
