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Molecular analysis of t(11;19) breakpoints in childhood acute leukemias
JE Rubnitz, FG Behm, AM Curcio-Brint, RP Pinheiro, AJ Carroll, SC Raimondi, SA Shurtleff and JR Downing
Department of Hematology/Oncology, St. Jude Children'sResearch Hospital,
Memphis, TN 38105, USA.
MLL is fused to ENL or ELL in acute leukemias that contain
t(ll;19)(q23;p13). Although ENL and ELL localize to chromosome 19, bands
p13.3 and p13.1, respectively, these breakpoints are not always readily
distinguished by standard cytogenetics. We therefore used reverse
transcriptase-polymerase chain reaction (RT-PCR) assays to analyze 26 cases
of childhood acute leukemia containing t(11;19) to determine the
frequencies of ENL and ELL involvement. All 17 cases of acute lymphoblastic
leukemia (ALL) had MLL/ENL fusion transcripts. By contrast, of the 9 cases
of acute myeloid leukemia (AML) analyzed, 6 had MLL/ENL fusions, 2 had
MLL/ELL fusions, and 1 case had no RT-PCR- detectable MLL fusion mRNA.
These data suggest that the majority of 11;19 translocations involve ENL,
whereas involvement of ELL is relatively uncommon in childhood acute
leukemia and may be restricted to AML.
Volume 87,
Issue 11,
pp. 4804-4808,
06/01/1996
Copyright © 1996 by The American Society of Hematology
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