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Expression of the interleukin-2 receptor gamma chain on cord blood
mononuclear cells
S Saito, T Morii, H Umekage, K Makita, K Nishikawa, N Narita, M Ichijo, H Morikawa, N Ishii, M Nakamura and K Sugamura
Department of Obsterics and Gynecology, Nara Medical University, Japan.
Lymphocytes in umbilical cord blood and neonatal peripheral blood have been
shown to have less ability in an immune reaction. In our present
experimental approach to address this issue, we made use of the cord blood
of full-term birth infants to investigate the expression of the
interleukin- 2 receptor gamma (IL-2Rgamma) chain that is shared with
receptors for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. The gamma chain
expression in cord blood lymphocytes was about one-third that in the
lymphocytes of adults, whereas no significant difference between cord blood
and adult monocytes was observed. A reduced expression of the gamma chain
was observed in all of the CD4+ T cells, CD8+ T cells, gamma-delta T cells,
B cells, CD16+ natural killer (NK) cells, and CD56(bright) NK cells of the
cord blood lymphocytes. The reduced gamma chain expression reached
two-thirds of that in adults after 3 days of culture in vitro and in
infants 3 days after birth, thus implying that the increase in the gamma
chain may significantly contribute to the prevention of neonatal infection.
Volume 87,
Issue 8,
pp. 3344-3350,
04/15/1996
Copyright © 1996 by The American Society of Hematology
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