|
|
 Previous Article | Table of Contents | Next Article 
Activation of naive and memory T cells by interleukin-15
H Kanegane and G Tosato
Division of Hematologic Products, Food and Drug Administration, Bethesda,
MD 20852, USA.
Interleukin-15 (IL-15), a product of monocytes and other cells, has
biological activities similar to those of IL-2, including growth
stimulation of activated T cells, induction of cytolytic effector cells,
and B-cell costimulation for proliferation and lg production. We report
that IL-15 at optimal concentrations rapidly induced memory (CD45RO+) CD4+
and CD8+ T cells and naive (CD45RO-) CD8+ T cells to express the CD69
activation marker followed by proliferation. By contrast, IL-15 failed to
induce naive (CD45RO-) CD4+ T cells to express CD69 or to proliferate.
Similar findings were obtained with IL- 2. Unlike the other T-cell subsets,
CD4+ T cells with a naive phenotype expressed little or no IL-2R beta
chain, a shared component of the IL-2 and IL-15 receptors required for
receptor function. A monoclonal antibody to the IL-2R beta chain, Mik beta
1, reduced CD69 expression and proliferation in CD4+ memory, CD8+ memory,
and CD8+ naive T cells activated by IL-15. These results confirm the
biological similarities of IL-2 and IL-15. They further document that the
pool of naive CD4+ cells, unlike the pool of memory CD4+, memory CD8+, and
naive CD8+ cells, is not regulated directly by the T-cell growth factors
IL-2 or IL-15.
Volume 88,
Issue 1,
pp. 230-235,
07/01/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Giron-Michel, F. Menard, S. Negrini, A. Devocelle, B. Azzarone, and C. Besson
EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15
Blood,
May 7, 2009;
113(19):
4541 - 4547.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. I. Kokaji, D. L. Hockley, and K. P. Kane
IL-15 Transpresentation Augments CD8+ T Cell Activation and Is Required for Optimal Recall Responses by Central Memory CD8+ T Cells
J. Immunol.,
April 1, 2008;
180(7):
4391 - 4401.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. M. Mueller, D. H. Do, S. R. Altork, C. M. Artlett, E. J. Gracely, C. D. Katsetos, A. Legido, F. Villinger, J. D. Altman, C. R. Brown, et al.
IL-15 Treatment during Acute Simian Immunodeficiency Virus (SIV) Infection Increases Viral Set Point and Accelerates Disease Progression despite the Induction of Stronger SIV-Specific CD8+ T Cell Responses
J. Immunol.,
January 1, 2008;
180(1):
350 - 360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. Uldrich, S. P. Berzins, M. A. Malin, P. Bouillet, A. Strasser, M. J. Smyth, R. L. Boyd, and D. I. Godfrey
Antigen challenge inhibits thymic emigration.
J. Immunol.,
April 15, 2006;
176(8):
4553 - 4561.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Roychowdhury, B. W. Blaser, A. G. Freud, K. Katz, D. Bhatt, A. K. Ferketich, V. Bergdall, D. Kusewitt, R. A. Baiocchi, and M. A. Caligiuri
IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease
Blood,
October 1, 2005;
106(7):
2433 - 2435.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-E. Miranda-Carus, M. Benito-Miguel, M. A. Llamas, A. Balsa, and E. Martin-Mola
Human T Cells Constitutively Express IL-15 That Promotes Ex Vivo T Cell Homeostatic Proliferation through Autocrine/Juxtacrine Loops
J. Immunol.,
September 15, 2005;
175(6):
3656 - 3662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Diaz, H. Foster, M. R. Stone, S. Fujimura, D. A. Relman, and J. A. Levy
VCAM-1 Expression on CD8+ Cells Correlates with Enhanced Anti-HIV Suppressing Activity
J. Immunol.,
February 1, 2005;
174(3):
1574 - 1579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Wysocka, B. M. Benoit, S. Newton, L. Azzoni, L. J. Montaner, and A. H. Rook
Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15
Blood,
December 15, 2004;
104(13):
4142 - 4149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ferrari-Lacraz, E. Zanelli, M. Neuberg, E. Donskoy, Y. S. Kim, X. X. Zheng, W. W. Hancock, W. Maslinski, X. C. Li, T. B. Strom, et al.
Targeting IL-15 Receptor-Bearing Cells with an Antagonist Mutant IL-15/Fc Protein Prevents Disease Development and Progression in Murine Collagen-Induced Arthritis
J. Immunol.,
November 1, 2004;
173(9):
5818 - 5826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Rivino, M. Messi, D. Jarrossay, A. Lanzavecchia, F. Sallusto, and J. Geginat
Chemokine Receptor Expression Identifies Pre-T Helper (Th)1, Pre-Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells
J. Exp. Med.,
September 20, 2004;
200(6):
725 - 735.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Castelli, E. K. Thomas, M. Gilliet, Y.-J. Liu, and J. A. Levy
Mature dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15
Blood,
April 1, 2004;
103(7):
2699 - 2704.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. J de Boer, A. E Becker, and A. C van der Wal
T lymphocytes in atherogenesis--functional aspects and antigenic repertoire
Cardiovasc Res,
October 15, 2003;
60(1):
78 - 86.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. L. Alves, B. Hooibrink, F. A. Arosa, and R. A. W. van Lier
IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro
Blood,
October 1, 2003;
102(7):
2541 - 2546.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Cavalieri, S. Cazzaniga, M. Geuna, Z. Magnani, C. Bordignon, L. Naldini, and C. Bonini
Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence
Blood,
July 15, 2003;
102(2):
497 - 505.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Geginat, A. Lanzavecchia, and F. Sallusto
Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines
Blood,
June 1, 2003;
101(11):
4260 - 4266.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Van Rhijn, L. H. Van den Berg, C. W. Ang, J. Admiraal, and T. Logtenberg
Expansion of human {gamma}{delta} T cells after in vitro stimulation with Campylobacter jejuni
Int. Immunol.,
March 1, 2003;
15(3):
373 - 382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. M. Mueller, P. M. Bojczuk, E. S. Halstead, A. H. J. Kim, J. Witek, J. D. Altman, and P. D. Katsikis
IL-15 enhances survival and function of HIV-specific CD8+ T cells
Blood,
February 1, 2003;
101(3):
1024 - 1029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. M. Mueller, V. Makar, P. M. Bojczuk, J. Witek, and P. D. Katsikis
IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells
Int. Immunol.,
January 1, 2003;
15(1):
49 - 58.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lu, R. L. Giuntoli II, R. Omiya, H. Kobayashi, R. Kennedy, and E. Celis
Interleukin 15 Promotes Antigen-independent in Vitro Expansion and Long-Term Survival of Antitumor Cytotoxic T Lymphocytes
Clin. Cancer Res.,
December 1, 2002;
8(12):
3877 - 3884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kurowska, W. Rudnicka, E. Kontny, I. Janicka, M. Chorazy, J. Kowalczewski, M. Ziolkowska, S. Ferrari-Lacraz, T. B. Strom, and W. Maslinski
Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients Express Functional IL-15 Receptor Complex: Endogenous IL-15 in Autocrine Fashion Enhances Cell Proliferation and Expression of Bcl-xL and Bcl-2
J. Immunol.,
August 15, 2002;
169(4):
1760 - 1767.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Fisher, J. Larson, C. Cool, and S. W. Dow
Lymphocyte Activation in the Lungs of SP-D Null Mice
Am. J. Respir. Cell Mol. Biol.,
July 1, 2002;
27(1):
24 - 33.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Heitger, P. Winklehner, P. Obexer, J. Eder, C. Zelle-Rieser, G. Kropshofer, M. Thurnher, and W. Holter
Defective T-helper cell function after T-cell-depleting therapy affecting naive and memory populations
Blood,
May 13, 2002;
99(11):
4053 - 4062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Liu, M. Catalfamo, Y. Li, P. A. Henkart, and N.-p. Weng
IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
PNAS,
April 18, 2002;
(2002)
92675799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-o. Lee, C. J. Cooper, J.-h. Choi, Z. Alnadjim, and T. A. Barrett
The State of CD4+ T Cell Activation Is a Major Factor for Determining the Kinetics and Location of T Cell Responses to Oral Antigen
J. Immunol.,
April 15, 2002;
168(8):
3833 - 3838.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Geginat, F. Sallusto, and A. Lanzavecchia
Cytokine-driven Proliferation and Differentiation of Human Naive, Central Memory, and Effector Memory CD4+ T Cells
J. Exp. Med.,
December 10, 2001;
194(12):
1711 - 1720.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. G. Neely, S. M. Robbins, E. K. Amankwah, S. Epelman, H. Wong, J. C. L. Spurrell, K. K. Jandu, W. Zhu, D. K. Fogg, C. B. Brown, et al.
Lipopolysaccharide-Stimulated or Granulocyte-Macrophage Colony-Stimulating Factor-Stimulated Monocytes Rapidly Express Biologically Active IL-15 on Their Cell Surface Independent of New Protein Synthesis
J. Immunol.,
November 1, 2001;
167(9):
5011 - 5017.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Wuttge, P. Eriksson, A. Sirsjo, G. K. Hansson, and S. Stemme
Expression of Interleukin-15 in Mouse and Human Atherosclerotic Lesions
Am. J. Pathol.,
August 1, 2001;
159(2):
417 - 423.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. A. Houtkamp, A. C. van der Wal, O. J. de Boer, C. M. van der Loos, P. A. J. de Boer, A. F. M. Moorman, and A. E. Becker
Interleukin-15 Expression in Atherosclerotic Plaques : An Alternative Pathway for T-Cell Activation in Atherosclerosis?
Arterioscler Thromb Vasc Biol,
July 1, 2001;
21(7):
1208 - 1213.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Fehniger and M. A. Caligiuri
Interleukin 15: biology and relevance to human disease
Blood,
January 1, 2001;
97(1):
14 - 32.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Masuko-Hongo, M. Kurokawa, T. Kobata, K. Nishioka, and T. Kato
Effect of IL15 on T cell clonality in vitro and in the synovial fluid of patients with rheumatoid arthritis
Ann Rheum Dis,
September 1, 2000;
59(9):
688 - 694.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Sun, L. Li, F. Lau, J. A. Beavo, and E. A. Clark
Infection of CD4+ Memory T Cells by HIV-1 Requires Expression of Phosphodiesterase 4
J. Immunol.,
August 15, 2000;
165(4):
1755 - 1761.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Dengler and J. S. Pober
Human Vascular Endothelial Cells Stimulate Memory But Not Naive CD8+ T Cells to Differentiate into CTL Retaining an Early Activation Phenotype
J. Immunol.,
May 15, 2000;
164(10):
5146 - 5155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Liu, K. Geboes, S. Colpaert, G. R. D'Haens, P. Rutgeerts, and J. L. Ceuppens
IL-15 Is Highly Expressed in Inflammatory Bowel Disease and Regulates Local T Cell-Dependent Cytokine Production
J. Immunol.,
April 1, 2000;
164(7):
3608 - 3615.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Kasyapa, C. L. Stentz, M. P. Davey, and D. W. Carr
Regulation of IL-15-Stimulated TNF-{alpha} Production by Rolipram
J. Immunol.,
September 1, 1999;
163(5):
2836 - 2843.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sancho, M. Yanez-Mo, R. Tejedor, and F. Sanchez-Madrid
Activation of Peripheral Blood T Cells by Interaction and Migration Through Endothelium: Role of Lymphocyte Function Antigen-1/Intercellular Adhesion Molecule-1 and Interleukin-15
Blood,
February 1, 1999;
93(3):
886 - 896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. I. Chapoval, J. A. Fuller, S. G. Kremlev, S. J. Kamdar, and R. Evans
Combination Chemotherapy and IL-15 Administration Induce Permanent Tumor Regression in a Mouse Lung Tumor Model: NK and T Cell-Mediated Effects Antagonized by B Cells
J. Immunol.,
December 15, 1998;
161(12):
6977 - 6984.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-N. Avice, C. E. Demeure, G. Delespesse, M. Rubio, M. Armant, and M. Sarfati
IL-15 Promotes IL-12 Production by Human Monocytes Via T Cell-Dependent Contact and May Contribute to IL-12-Mediated IFN-{gamma} Secretion by CD4+ T Cells in the Absence of TCR Ligation
J. Immunol.,
October 1, 1998;
161(7):
3408 - 3415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. H. Orteu, L. W. Poulter, M. H. A. Rustin, C. A. Sabin, M. Salmon, and A. N. Akbar
The Role of Apoptosis in the Resolution of T Cell-Mediated Cutaneous Inflammation
J. Immunol.,
August 15, 1998;
161(4):
1619 - 1629.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ruchatz, B. P. Leung, X.-q. Wei, I. B. McInnes, and F. Y. Liew
Soluble IL-15 Receptor {alpha}-Chain Administration Prevents Murine Collagen-Induced Arthritis: A Role for IL-15 in Development of Antigen-Induced Immunopathology
J. Immunol.,
June 1, 1998;
160(11):
5654 - 5660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ke, H. Ma, and J. A. Kapp
Antigen Is Required for the Activation of Effector Activities, whereas Interleukin 2 Is Required for the Maintenance of Memory in Ovalbumin-specific, CD8+ Cytotoxic T Lymphocytes
J. Exp. Med.,
January 5, 1998;
187(1):
49 - 57.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. David, L. Bani, J.-L. Moreau, C. Demaison, K. Sun, O. Salvucci, T. Nakarai, M. de Montalembert, S. Chouaib, M. Joussemet, et al.
Further Analysis of Interleukin-2 Receptor Subunit Expression on the Different Human Peripheral Blood Mononuclear Cell Subsets
Blood,
January 1, 1998;
91(1):
165 - 172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Korholz, U. Banning, H. Bonig, M. Grewe, M. Schneider, C. Mauz-Korholz, A. Klein-Vehne, J. Krutmann, and S. Burdach
The Role of Interleukin-10 (IL-10) in IL-15-Mediated T-Cell Responses
Blood,
December 1, 1997;
90(11):
4513 - 4521.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Agostini, L. Trentin, R. Sancetta, M. Facco, C. Tassinari, A. Cerutti, M. Bortolin, A. Milani, M. Siviero, R. Zambello, et al.
Interleukin-15 Triggers Activation and Growth of the CD8 T-Cell Pool in Extravascular Tissues of Patients With Acquired Immunodeficiency Syndrome
Blood,
August 1, 1997;
90(3):
1115 - 1123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. F. Tough, S. Sun, and J. Sprent
T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)
J. Exp. Med.,
June 16, 1997;
185(12):
2089 - 2094.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Liu, M. Catalfamo, Y. Li, P. A. Henkart, and N.-p. Weng
IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
PNAS,
April 30, 2002;
99(9):
6192 - 6197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
