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Suicide gene therapy for plasma cell tumors
MS Dilber, MR Abedi, B Bjorkstrand, B Christensson, G Gahrton, KG Xanthopoulos and CI Smith
Department of Medicine, Karolinska Institute at Huddinge Hospital, Sweden.
Suicide gene therapy for plasma cell tumors was attempted in severe
combined immunodeficient (SCID) mice injected with human myeloma cell
lines. Initially, a ganciclovir-induced bystander effect was observed in
vitro using myeloma cells transduced with a herpes simplex thymidine kinase
(HSVtk) gene. Transduced cells injected subcutaneously (SC) into SCID mice
could be eradicated by the administration of ganciclovir (GCV).
Furthermore, an in vivo bystander effect was noticed when mice received
mixtures of HSVtk-positive and nontransduced cells. Unexpectedly, a
"distant bystander" effect was observed as tumors in regions inoculated
with only nontransduced cells were significantly smaller and had increased
frequency of apoptotic figures and decreased mitotic frequency in
GCV-treated mice transplanted with HSVtk-positive cells at a different
region compared with control mice.
Volume 88,
Issue 6,
pp. 2192-2200,
09/15/1996
Copyright © 1996 by The American Society of Hematology
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