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Differential regulation of proinflammatory and hematopoietic cytokines in
human macrophages after infection with human immunodeficiency virus
R Esser, W Glienke, H von Briesen, H Rubsamen-Waigmann and R Andreesen
Georg-Speyer-Haus, Frankfurt am Main, Germany.
Cells of the macrophage lineage (MAC) play an important role in human
immunodeficiency virus (HIV) infection. However, the knowledge on the
extent of macrophage involvement in the pathogenesis of HIV infection is
still incomplete. In this study we examined the secretory repertoire of
HIV-infected MAC with respect to the proinflammatory cytokines tumor
necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), IL- 6,
IL-8, and the hematopoietic growth factors M-, G- and granulocyte-
macrophage colony stimulating factor (GM-CSF). Using a culture system on
hydrophobic teflon membranes, blood-derived MO from healthy donors were
infected with a monocytotropic HIV-1 isolate (HIV-1D117IIII). We analyzed
the constitutive and lipopolysaccharides-stimulated secretion of MO/MAC
early after infection as well as in long-term cultured, virus- replicating
cells. The release of proinflammatory mediators and hematopoietic growth
factors were differentially regulated after infection with HIV: the
secretion of TNF-alpha, IL-1 beta, IL-6, IL-8 was upregulated, whereas a
down-regulation of M-, G-, and GM-CSF could be observed. These results may
provide some explanation for the immunological dysfunction, the
hematopoietic failure and the chronic inflammatory disease occurring in
HIV-infected patients.
Volume 88,
Issue 9,
pp. 3474-3481,
11/01/1996
Copyright © 1996 by The American Society of Hematology
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